{
  "abstract": "Objectives: To systematically analyze the content and format of research priorities in clinical practice guidelines (CPGs) for migraine, providing a methodological guidance for future guideline developers and researchers. Methods: This methodological systematic analysis involved searching six databases (Embase, PubMed CNKI, VIP, CBM and Wanfang) and the official websites of 39 authoritative organizations, including headache societies, neurology associations, and guideline development bodies. Extract information such as the name, type, and quantity of research priorities. Two reviewers independently performed data retrieval, screening, and extraction. Descriptive statistics were used to calculate the absolute frequencies and proportions of research-focused items. We have registered at INPLASY with the registration number INPLASY2025120098. Results: Out of 96 included CPGs, 248 research priorities were identified. Only half (48, 50%) of the CPGs explicitly reported research priorities, and only 13.5% (13) included a dedicated section. The primary rationale for proposing these priorities was a lack of sufficient evidence (108, 43.5%). The nomenclature for research priorities varies widely, and structured reporting was found to be inadequate. Furthermore, 56% of priorities (139) focused on the effectiveness of interventions, primarily concerning calcitonin gene-related peptide (CGRP) monoclonal antibodies (20, 8.1%), angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) (18, 7.3%), and antiepileptic drugs (17, 6.9%). Conclusions: The reporting of research priorities in migraine CPGs—both in content and format—requires significant improvement. Future efforts should prioritize the systematic identification and standardized reporting of research gaps in migraine and other disease areas.",
  "abstract_shown": true,
  "affiliations": [
    "The Second Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China",
    "The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China",
    "College of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuejian Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yingdi Liao"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhuo Ye"
    },
    {
      "name": "Yiyun Zhao"
    },
    {
      "name": "Shiyu An"
    },
    {
      "name": "Riai Tang"
    },
    {
      "name": "Qinyan Li"
    },
    {
      "name": "Shuting Yang"
    },
    {
      "name": "Yuze Sun"
    },
    {
      "name": "Yicheng Gao"
    },
    {
      "name": "Kai Yuan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3sq3x9avdxgqt.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0361302",
  "fulltext_url": "https://europepmc.org/articles/PMC13722188",
  "id": "3sq3x9avdxgqt",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0361302",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Medicine"
    ],
    [
      "heading",
      "Clinical Research Design"
    ],
    [
      "heading",
      "Database Searching"
    ],
    [
      "heading",
      "Database and Informatics Methods"
    ],
    [
      "heading",
      "Drug Research and Development"
    ],
    [
      "heading",
      "Headaches"
    ],
    [
      "heading",
      "Health Care"
    ],
    [
      "heading",
      "Health Care Policy"
    ],
    [
      "heading",
      "Medicine and Health Sciences"
    ],
    [
      "heading",
      "Migraine"
    ],
    [
      "heading",
      "Pharmacology"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "heading",
      "Research Design"
    ],
    [
      "heading",
      "Research and Analysis Methods"
    ],
    [
      "heading",
      "Screening Guidelines"
    ],
    [
      "heading",
      "Signs and Symptoms"
    ],
    [
      "heading",
      "Treatment Guidelines"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Headaches"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Headaches/Migraine"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Health care policy/Screening guidelines"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Health care policy/Treatment guidelines"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmacology/Drug research and development"
    ],
    [
      "plos",
      "/Research and analysis methods/Database and informatics methods/Database searching"
    ],
    [
      "plos",
      "/Research and analysis methods/Research design"
    ],
    [
      "plos",
      "/Research and analysis methods/Research design/Clinical research design"
    ]
  ],
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  "pdf_url": "https://europepmc.org/articles/PMC13722188?pdf=render",
  "pmcid": "PMC13722188",
  "pmid": "42961969",
  "published": "2026-10-30",
  "publisher": "Public Library of Science",
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    {
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:pharmacology",
      "subfield": "pharmacology-toxicology"
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  "title": "Reporting of research priorities in migraine clinical practice guidelines still need improvement—A methodological analysis",
  "title_text": "Reporting of research priorities in migraine clinical practice guidelines still need improvement—A methodological analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:44Z",
  "url": "https://research.draconitic.com/paper/3sq3x9avdxgqt",
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}