{
  "abstract": "A new clickable radical fluoroalkylating reagent, sodium 2-azido-1,1,2,2-tetrafluoroethanesulfinate, was prepared in one step from tetrafluoroethylene, sodium azide and sulfur dioxide. Oxidant-induced radical fluoroalkylation of arenes, heteroarenes, alkenes, and thiols, using this reagent, afforded azidotetrafluoroalkylated adducts. Their subsequent click reactions with alkynes led to N-fluoroalkylated triazoles. The synthetic sequence demonstrated the use of the new reagent as a clickable azidotetrafluoroethyl radical synthon, enabling connection to a diverse array of moieties, including a monoclonal antibody, via a triazole linker.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Flemingovo nam. 2 160 00 Prague Czechia",
    "Department of Chemistry, Faculty of Science, Charles University Hlavova 2030/8 128 43 Prague Czechia",
    "Department of Chemistry, Northeast Normal University 5286 Renmin Street Changchun 130024 China",
    "Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice Studentská 573 532 10 Pardubice Czechia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pallavi Halkarni",
      "orcid": "0009-0004-8950-4922"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mykyta Ziabko"
    },
    {
      "affs": [
        0
      ],
      "name": "Veronika Vrábelová",
      "orcid": "0000-0001-8560-3916"
    },
    {
      "affs": [
        0
      ],
      "name": "Marek Opelka"
    },
    {
      "affs": [
        2
      ],
      "name": "Yu Qianfei"
    },
    {
      "affs": [
        2
      ],
      "name": "Xihe Bi",
      "orcid": "0000-0002-6694-6742"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergeii Suikov"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Petr Pospíšil"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomáš David"
    },
    {
      "affs": [
        0
      ],
      "name": "Soňa Boháčová"
    },
    {
      "affs": [
        0
      ],
      "name": "Blanka Klepetářová"
    },
    {
      "affs": [
        0
      ],
      "name": "Petr Beier",
      "orcid": "0000-0002-0888-7465"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3syxacf7091vg.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06249k",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13576151/",
  "id": "3syxacf7091vg",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc06249k",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7213363591",
  "pdf_url": null,
  "pmcid": "PMC13576151",
  "pmid": "42746477",
  "published": "2026-09-15",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/3syxacf7091vg.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:29Z",
      "native_id": "PMC13576151",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc06249k"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Fluorine in Organic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "A sulfinate–azide hybrid reagent for sequential radical fluoroalkylation and click reaction†",
  "title_text": "A sulfinate–azide hybrid reagent for sequential radical fluoroalkylation and click reaction†",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:58Z",
  "url": "https://research.draconitic.com/paper/3syxacf7091vg",
  "venue": "Chemical Science",
  "versions": []
}