{
  "abstract": "Purpose: Chatbots are increasingly delivering genetic services, and we have shown equivalence between chatbot and standard of care (SOC) in the uptake of pretest genetic services and genetic testing. Here, we compare patients’ perceptions and cognitive and emotional responses to these 2 service delivery models.\n\nMethods: Unaffected primary care patients aged 25 to 60 years who met family history–based criteria for genetic evaluation were randomized 1:1 to chatbot or SOC arms. Four weeks after completing genetic services, we surveyed participants to assess their perceptions and cognitive and emotional responses; we compared these between arms using one-way analyses of covariance and logistic regressions, adjusting for demographic and clinical covariates.\n\nResults: Participants (N = 189) had highly or moderately positive perceptions of services and cognitive and emotional responses, and these were similar between arms. However, chatbot participants reported statistically significantly lower satisfaction with counseling (P = .026) and education (P = .005), attention maintenance (P = .001), and emotional support (P < .001) than SOC participants. Among those who received testing, chatbot participants reported significantly lower perceived utility (P = .044) and lower distress (P = .025) related to test results.\n\nConclusion: Patients reported positive perceptions and responses to both SOC and chatbot-delivered genetic services. However, enhancing emotional responsiveness and personalization may further improve the experience and perceived utility with chatbots.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Communication, University of Utah, Salt Lake City, UT",
    "Huntsman Cancer Institute, Salt Lake City, UT",
    "Department of Biostatistics and Center for Anti-Racism, Social Justice & Public Health, School of Global Public Health, New York University, New York, NY",
    "Department of Biostatistics, School of Global Public Health, New York University, New York, NY",
    "Perlmutter Cancer Center, NYU Langone Health, New York, NY",
    "Breast/Gynecologic System of Excellence, VA Medical Center National TeleOncology, Durham, NC",
    "Department of Population Health Sciences, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT",
    "Department of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT",
    "Department of Population Health, NYU Grossman School of Medicine, New York, NY",
    "Center for Health Outcomes and Population Equity (HOPE), Huntsman Cancer Institute, Salt Lake City, UT",
    "Department of Biomedical Informatics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yang Yi"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jemar R. Bather"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Melody S. Goodman"
    },
    {
      "affs": [
        4
      ],
      "name": "Rachelle Lorenz Chambers"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Sarah V. Colonna"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Rachel Hess"
    },
    {
      "affs": [
        1
      ],
      "name": "Wendy K. Kohlmann"
    },
    {
      "affs": [
        1
      ],
      "name": "Whitney F. Maxwell"
    },
    {
      "affs": [
        4,
        8
      ],
      "name": "Rachel Monahan"
    },
    {
      "affs": [
        6,
        9
      ],
      "name": "David W. Wetter"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "Saundra S. Buys"
    },
    {
      "affs": [
        10
      ],
      "name": "Kensaku Kawamoto"
    },
    {
      "affs": [
        10
      ],
      "name": "Guilherme Del Fiol"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kimberly A. Kaphingst"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3tqccsqmmdhbw.bib",
  "cited_by": 0,
  "doi": "10.1016/j.gimo.2026.104498",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734811/",
  "id": "3tqccsqmmdhbw",
  "issns": [
    "2949-7744"
  ],
  "landing_url": "https://doi.org/10.1016/j.gimo.2026.104498",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Report"
    ],
    [
      "openalex",
      "1311|BRCA gene mutations in cancer"
    ]
  ],
  "openalex": "W7214175915",
  "pdf_url": "https://www.gimopen.org/article/S2949-7744(26)01008-3/pdf",
  "pmcid": "PMC13734811",
  "pmid": "42990828",
  "published": "2026-09-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/3tqccsqmmdhbw.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:38Z",
      "native_id": "PMC13734811",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.gimo.2026.104498"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|BRCA gene mutations in cancer",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Comparing patients’ perceptions and cognitive and emotional responses to pretest cancer genetic services delivered via chatbot vs standard of care: Findings from the BRIDGE trial",
  "title_text": "Comparing patients’ perceptions and cognitive and emotional responses to pretest cancer genetic services delivered via chatbot vs standard of care: Findings from the BRIDGE trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:38Z",
  "url": "https://research.draconitic.com/paper/3tqccsqmmdhbw",
  "venue": "Genetics in Medicine Open",
  "versions": []
}