{
  "abstract": "Research on cellular senescence and the senescence-associated secretory phenotype (SASP) draws on independently curated gene resources that differ in scope, identifiers, and update cycles, making cross-resource integration error-prone. We unified four widely used resources, CellAge, GenAge, the SenMayo signature, and the Reactome Cellular Senescence pathway, onto a single canonical identifier (the Ensembl gene ID) and enriched every gene with three annotation layers absent from all four inputs: cross-species conservation, tissue and cell-type expression, and high-confidence protein-protein interactions. Unification collapsed 1,460 summed source entries into 1,250 unique genes (210 redundant entries removed, 14.4%) while preserving full source provenance: 173 genes are corroborated by two or more resources and two (IL6, JUN) by all four. The three annotation layers reach 95.8%, 97.9%, and 93.0% of genes, with 89.4% annotated across all three. A 500-gene random sample of identifier mappings was validated against HGNC and Ensembl (98.0% exact match). The result, SenSASP, is a single, machine-readable, provenance-tracked database of harmonized identifiers and net-new functional context, illustrated here with a gene-prioritization score and a tissue-expression atlas. SenSASP is freely available at https://xuan13hao.github.io/sensasp/",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.13322",
  "author_total": 3,
  "authors": [
    {
      "name": "Hao Xuan"
    },
    {
      "name": "Yu Huang"
    },
    {
      "name": "Jiang Bian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3tv2qfbn1a5a8.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.13322",
  "fulltext_url": null,
  "id": "3tv2qfbn1a5a8",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.13322",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.OT"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2609.13322",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3tv2qfbn1a5a8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:30Z",
      "native_id": "2609.13322",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.13322"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.OT",
      "subfield": "general"
    }
  ],
  "title": "SenSASP: A Unified, Multi-Layer Database of Senescence and SASP Genes",
  "title_text": "SenSASP: A Unified, Multi-Layer Database of Senescence and SASP Genes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:30Z",
  "url": "https://research.draconitic.com/paper/3tv2qfbn1a5a8",
  "venue": "arXiv",
  "versions": []
}