{
  "abstract": "BACKGROUND: 3D-FLAIR is central to MR-based diagnosis and monitoring of MS, but long acquisition times remain a limitation. OBJECTIVES: This single-center prospective non-inferiority study evaluated whether compressed sensing (CS) - accelerated 3D-FLAIR at 1.5T provides lesion detection comparable to optimized Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA) - accelerated 3D-FLAIR. Optimized CS- and GRAPPA-accelerated 3D-FLAIR sequences were incorporated into MRI examinations in patients with known or suspected MS. The primary endpoint was manual lesion count by two blinded readers using a 10% non-inferiority margin. Secondary endpoints included image quality, SNR, CNR, and automated lesion count and volumetry. RESULTS: Sixty-eight patients were included (mean age, 40.1+/-13.3 years; 61.8% women). CS-accelerated 3D-FLAIR reduced acquisition time by 31.8% compared with GRAPPA (4:00 vs 5:52 minutes). Non-inferiority for manual lesion count was demonstrated for both readers (reader A, p < .0001; reader B, p = .005). Interrater agreement was excellent for CS (ICC = 0.921; 95% CI, 0.837-0.957) and very good for GRAPPA (ICC = 0.851; 95% CI, 0.769-0.906). Subjective image quality was high for both techniques. GRAPPA showed higher objective signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR), whereas automated lesion counts and volumes were higher for CS. CONCLUSION: CS-accelerated 3D-FLAIR provided non-inferior lesion detection with substantial scan-time reduction.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus Oldenburg, Steinweg 13-17, 26122 Oldenburg, Niedersachsen, Germany"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "C. G. Iacoban"
    },
    {
      "name": "C. Klüner"
    },
    {
      "name": "H. Bösenberg"
    },
    {
      "name": "O. Alykova"
    },
    {
      "name": "M. Gerdes"
    },
    {
      "name": "S. Reuter"
    },
    {
      "name": "C. Mathys"
    },
    {
      "name": "B. Sundermann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3txbkdx7xkf6g.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.02.26367062",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367062v1.full",
  "id": "3txbkdx7xkf6g",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367062v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "radiology and imaging"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367062v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3txbkdx7xkf6g.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:04Z",
      "native_id": "10.64898/2026.11.02.26367062",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367062v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:radiology and imaging",
      "subfield": "imaging"
    }
  ],
  "title": "ACCURACY OF COMPRESSED SENSING ACCELERATED 3D-FLAIR IN THE DIAGNOSTIC WORK-UP OF MULTIPLE SCLEROSIS AT 1.5 T",
  "title_text": "ACCURACY OF COMPRESSED SENSING ACCELERATED 3D-FLAIR IN THE DIAGNOSTIC WORK-UP OF MULTIPLE SCLEROSIS AT 1.5 T",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:36Z",
  "url": "https://research.draconitic.com/paper/3txbkdx7xkf6g",
  "venue": "medRxiv",
  "versions": []
}