{
  "abstract": "Drug‐induced thrombocytopenia is a condition where certain medications can significantly reduce the platelets in the blood. This can increase the risk of bleeding and bruising. We reported a case of a 73‐year‐old woman with multiple comorbidities who was admitted to the hospital with COVID‐19. Upon admission, the patient received multiple antibiotics, including Piperacillin/Tazobactam. In the following days, she developed severe thrombocytopenia upon re‐exposure to Piperacillin/Tazobactam. Other causes of thrombocytopenia were systematically excluded. After discontinuing the Piperacillin/Tazobactam and administering intravenous immunoglobulin (IVIG), the thrombocytopenia resolved. A Naranjo Adverse Drug Reaction Probability Scale score was calculated and indicated a probable (i.e., 6 points) adverse drug reaction. This case underscores the importance of considering Piperacillin/Tazobactam as a potential cause of severe thrombocytopenia in critically ill patients, even in the presence of confounding factors such as COVID‐19. To our knowledge, this is a rarely reported presentation in a patient with a recent COVID‐19 infection. Further studies are needed to clarify the relationship between COVID‐19 and drug‐induced thrombocytopenia.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Pharmacy, College of Pharmacy Shaqra University Al‐Dawadmi Saudi Arabia",
    "Pharmaceutical Care Division King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia",
    "Pharmaceutical Care Department King Abdulaziz Medical City Riyadh Saudi Arabia",
    "College of Pharmacy King Saud Bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia",
    "Clinical Trial Management King Abdullah International Medical Research Center Riyadh Saudi Arabia",
    "Department of Pharmacy Practice, Faculty of Pharmacy King Abdulaziz University Jeddah Saudi Arabia",
    "Pharmaceutical Care Administration King Saud Medical City Riyadh Saudi Arabia",
    "Saudi Critical Care Pharmacy Research (SCAPE) Platform Riyadh Saudi Arabia",
    "Saudi Society for Multidisciplinary Research Development and Education (SCAPE Society) Riyadh Saudi Arabia"
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Abdullah F. Alharthi",
      "orcid": "0009-0004-4706-4076"
    },
    {
      "affs": [
        1
      ],
      "name": "Munirah A. Alkathiri"
    },
    {
      "affs": [
        0
      ],
      "name": "Othman Alomeir"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Shmeylan Al Harbi"
    },
    {
      "affs": [
        5
      ],
      "name": "Ohoud Aljuhani"
    },
    {
      "affs": [
        6
      ],
      "name": "Haifa A. Alhaidal"
    },
    {
      "affs": [
        2,
        3,
        4,
        7,
        8
      ],
      "name": "Khalid Al Sulaiman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3v0cqb2mswfy6.bib",
  "cited_by": 0,
  "doi": "10.1002/ccr3.73787",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721160/?tool=EBI",
  "id": "3v0cqb2mswfy6",
  "issns": [
    "2050-0904"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13721160",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Critical Care Medicine"
    ],
    [
      "heading",
      "Infectious Diseases"
    ],
    [
      "heading",
      "Medical Education"
    ],
    [
      "heading",
      "Pharmacology and Pharmacy"
    ],
    [
      "openalex",
      "2720|Platelet Disorders and Treatments"
    ]
  ],
  "openalex": "W4392536049",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721160/pdf/?tool=EBI",
  "pmcid": "PMC13721160",
  "pmid": "42964650",
  "published": "2026-10-30",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/3v0cqb2mswfy6.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13721160",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13721160"
    },
    {
      "first_seen": "2026-11-03T12:21:54Z",
      "native_id": "PMC13721160",
      "source": "pmc",
      "url": "https://doi.org/10.1002/ccr3.73787"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Infectious Diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Severe Thrombocytopenia Induced by Re‐Exposure to Piperacillin/Tazobactam: A Case Report in Critically Ill Patient With COVID‐19",
  "title_text": "Severe Thrombocytopenia Induced by Re‐Exposure to Piperacillin/Tazobactam: A Case Report in Critically Ill Patient With COVID‐19",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:54Z",
  "url": "https://research.draconitic.com/paper/3v0cqb2mswfy6",
  "venue": "Clinical case reports",
  "versions": []
}