{
  "abstract": "Osteosarcoma cells encounter distinct extracellular environments during primary growth, treatment, detachment, and pulmonary colonization. A single constitutive extracellular-matrix (ECM)–integrin–FAK–AKT pathway therefore cannot explain residual disease and metastasis. This Review proposes matrix-state switching as a stage-resolved framework jointly defined by ligand presentation, adhesion-receptor usage, matrix-coupled signaling dependencies, and the cellular compartment sustaining these interactions. The framework is not an obligatory linear trajectory: observed state differences may reflect reversible adaptation, selection of pre-existing populations, therapy-associated remodeling, or combinations thereof. Primary lesions show component-selective matrix-conditioned drug tolerance; detached cells can preserve Src-dependent PI3K–AKT survival despite loss of sustained FAK and paxillin phosphorylation; and pulmonary colonization introduces distinct tumor-cell and stromal dependencies, including β4–ezrin-associated signaling and the CXCL14–α11β1 fibroblast circuit. Recent single-cell and spatial studies further indicate therapy-associated ECM remodeling and residual malignant-cell programs involving stemness, epithelial–mesenchymal transition, ECM interaction, and PI3K signaling, but do not establish same-clone longitudinal switching. LAMC1 is evaluated strictly as a hypothesis-generating matrix-state candidate because current osteosarcoma-specific evidence remains transcript-level. We position matrix-state switching as a matrix- and adhesion-focused layer within the broader communication-driven osteosarcoma ecosystem and define falsifiable criteria for distinguishing functional state dependencies from association.",
  "abstract_shown": true,
  "affiliations": [
    "Trauma Orthopedics Center, Ningbo No.6 Hospital, Ningbo, Zhejiang, China",
    "Ningbo Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Ningbo, Zhejiang, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yang Gu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yunqiang Zhuang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3v0tjj8nqttag.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1987843",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736186/",
  "id": "3v0tjj8nqttag",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://doi.org/10.3389/fcell.2026.1987843",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2730|Sarcoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223179727",
  "pdf_url": "https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1987843/pdf",
  "pmcid": "PMC13736186",
  "pmid": "42991569",
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3v0tjj8nqttag.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:42Z",
      "native_id": "PMC13736186",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcell.2026.1987843"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Sarcoma Diagnosis and Treatment",
      "subfield": "oncology"
    }
  ],
  "title": "Matrix-state switching in osteosarcoma under therapeutic pressure: integrin rewiring, residual disease, and pulmonary niche adaptation",
  "title_text": "Matrix-state switching in osteosarcoma under therapeutic pressure: integrin rewiring, residual disease, and pulmonary niche adaptation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:42Z",
  "url": "https://research.draconitic.com/paper/3v0tjj8nqttag",
  "venue": "Frontiers in Cell and Developmental Biology",
  "versions": []
}