{
  "abstract": "Emerging evidence associates CXCR5 expression with immunotherapy outcomes; however, the intrinsic role of tumor-derived CXCR5 in modulating chemo-immunotherapy sensitivity in triple-negative breast cancer (TNBC) remains uncharacterized. This study was conducted using murine 4T1 and human MDA-MB-231 TNBC models. Tumor cell CXCR5 expression was manipulated through overexpression or shRNA-mediated silencing. Therapeutic efficacy of paclitaxel (PTX, 10 mg/kg)±Tislelizumab (TIS, 10 mg/kg) was evaluated using in vivo tumor models and T cell cytotoxicity assays. We demonstrated that combination therapy effectively suppressed 4T1 tumor growth, extended survival, and enhanced intratumoral CD8⁺/GZMB⁺T cell infiltration coupled with increased cleaved-caspase-3 activation in murine studies. In vitro analyses revealed that CXCR5-high MDA-MB-231 cells exhibited heightened sensitivity to T-cell-mediated cytotoxicity in combination with PTX+TIS, corresponding with decreased BCL2 expression and elevated BAX levels. Our findings establish tumor-intrinsic CXCR5 as a pivotal determinant of chemo-immunotherapy efficacy in TNBC, mechanistically linked to enhanced CD8⁺T cell infiltration and apoptotic signaling.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Weihong Feng"
    },
    {
      "name": "Jin Yan"
    },
    {
      "name": "Xue Gong"
    },
    {
      "name": "Jiandong Hu"
    },
    {
      "name": "Mengli Jin"
    },
    {
      "name": "Chunhua Ma"
    },
    {
      "name": "Fenge Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3v3wk8y9g5fjp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117874",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717742/?tool=EBI",
  "id": "3v3wk8y9g5fjp",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03257-8",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Health sciences"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "heading",
      "Oncology"
    ],
    [
      "openalex",
      "2730|Chemokine receptors and signaling"
    ]
  ],
  "openalex": "W7223100307",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717742/pdf/?tool=EBI",
  "pmcid": "PMC13717742",
  "pmid": "42959908",
  "published": "2026-10-21",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/3v3wk8y9g5fjp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117874",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03257-8"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117874",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032578"
    },
    {
      "first_seen": "2026-10-31T00:20:38Z",
      "native_id": "PMC:PMC13717742",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717742"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42959908",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959908"
    },
    {
      "first_seen": "2026-11-02T12:22:00Z",
      "native_id": "PMC13717742",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117874"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "heading:Oncology",
      "subfield": "oncology"
    }
  ],
  "title": "CXCR5 regulates CD8+/GZMB+ T cell infiltration and apoptotic signaling in breast cancer",
  "title_text": "CXCR5 regulates CD8+/GZMB+ T cell infiltration and apoptotic signaling in breast cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:00Z",
  "url": "https://research.draconitic.com/paper/3v3wk8y9g5fjp",
  "venue": "iScience",
  "versions": []
}