{
  "abstract": "Objective:: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related mortality worldwide, with over 1.9 million new cases and 0.9 million deaths reported in 2020. The role of Helicobacter pylori infection in CRC pathogenesis remains a significant area of research. This study aimed to investigate the association between H. pylori infection, and genetic alterations in CRC patients.\n\nMethods:: A total of 110 blood and tissue biopsy samples were collected from CRC patients at Ghazi AL-Hariri Specialized Surgery Hospital in Baghdad, Iraq, between November 2023 and August 2024. An additional 36 samples from non-cancer patients were used as controls. Enzyme-linked immunosorbent assay (ELISA) was employed to detect H. pylori-specific immunoglobulins (IgG). Gene expression analysis of ELASTIN, TIMP3, K-RAS, and BRAF was performed using RT-qPCR.\n\nResults:: The study found that H. pylori infection was present in 79.5% of CRC patients, with significant IgG seropositivity (p < 0.05). Gene expression analysis revealed a significant downregulation of TIMP3 and alterations in ELASTIN, K-RAS, and BRAF (p < 0.01).\n\nConclusion:: In conclusion, chronic H. pylori infection may contribute to CRC pathogenesis through sustained inflammation and genetic dysregulation. The study highlights TIMP3 suppression as a potential factor in CRC progression, warranting further investigation into its clinical implications.",
  "abstract_shown": true,
  "affiliations": [
    "Botany and Microbiology Department, Faculty of science, Cairo University, Egypt.",
    "Microbiology Department, Collage of Medicine, Al-Iraqia University, Iraq."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ayat Majeed Zeadan"
    },
    {
      "affs": [
        0
      ],
      "name": "Tarek A.A. Mousaa"
    },
    {
      "affs": [
        1
      ],
      "name": "Ahmed Rushdi Abdullah"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3v5a5454hpfkj.bib",
  "cited_by": 2,
  "doi": "10.31557/apjcp.2026.27.6.2287",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13726732/",
  "id": "3v5a5454hpfkj",
  "issns": [
    "1513-7368",
    "2476-762X"
  ],
  "landing_url": "https://doi.org/10.31557/apjcp.2026.27.6.2287",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2746|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7165926994",
  "pdf_url": "https://journal.waocp.org/article_92250_beacd0d05fbf9d26a955c2101c15a22c.pdf",
  "pmcid": "PMC13726732",
  "pmid": "42345178",
  "published": "2026-06-22",
  "publisher": "Shahid Beheshti University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/3v5a5454hpfkj.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:23:00Z",
      "native_id": "PMC13726732",
      "source": "pmc",
      "url": "https://doi.org/10.31557/apjcp.2026.27.6.2287"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Helicobacter pylori-related gastroenterology studies",
      "subfield": "surgery"
    }
  ],
  "title": "Gene Expression Alterations of TIMP3, ELASTIN, K-RAS, and BRAF in Colorectal Cancer Patients with H. pylori Infection",
  "title_text": "Gene Expression Alterations of TIMP3, ELASTIN, K-RAS, and BRAF in Colorectal Cancer Patients with H. pylori Infection",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:37Z",
  "url": "https://research.draconitic.com/paper/3v5a5454hpfkj",
  "venue": "Asian Pacific Journal of Cancer Prevention : APJCP",
  "versions": []
}