{
  "abstract": "Recording cellular histories requires continued information accumulation while retaining earlier records. Infinite Printer couples DNA self-extension to regeneration of a writable terminal context. A single self-targeting prime-editing guide directs repeat extension, while base editing diversifies the accessible sequence in situ. A separate configuration uses auxiliary guides for specified payload writing. After three rounds of payload input, 4,436 distinct complete records contained identities from all three pools. Extended AC/AT records retained shared upstream marks, and complete-sequence readout distinguished endpoints sharing initial prefixes. Joint single-cell readout recovered 1,549 records and 7,669 combinations across 12,302 transcriptome-linked cell labels; spatial readout linked records to 11,330 capture spots. These results establish a resource for self-extending stochastic and programmed DNA recording with joint cellular and tissue readout, providing a foundation for future lineage applications.",
  "abstract_shown": true,
  "affiliations": [
    "The First Affiliated Hospital of Sun Yat-sen University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Z. Zhang"
    },
    {
      "name": "Y. Li"
    },
    {
      "name": "Y. Peng"
    },
    {
      "name": "R. Ling"
    },
    {
      "name": "K. Li"
    },
    {
      "name": "M. Cheng"
    },
    {
      "name": "Y. Cheng"
    },
    {
      "name": "C. Zhang"
    },
    {
      "name": "X. Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Chen"
    },
    {
      "name": "Z. He"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3vatf6txrn522.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.759016",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759016v1.full",
  "id": "3vatf6txrn522",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759016v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "synthetic biology"
    ],
    [
      "openalex",
      "1312|CRISPR and Genetic Engineering"
    ]
  ],
  "openalex": "W7222586693",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759016v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3vatf6txrn522.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:03Z",
      "native_id": "10.64898/2026.10.14.759016",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759016v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:synthetic biology",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Self-extending DNA recording with stochastic and programmed writing",
  "title_text": "Self-extending DNA recording with stochastic and programmed writing",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:16Z",
  "url": "https://research.draconitic.com/paper/3vatf6txrn522",
  "venue": "bioRxiv",
  "versions": []
}