{
  "abstract": "Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of antiresorptive therapy, yet no reliable circulating biomarker exists for risk stratification. Using an unbiased serum proteomics approach in a multicentre framework, we identified dopamine β-hydroxylase (DBH) as a differentially expressed protein with significantly lower levels in patients with MRONJ. This finding was validated in an independent clinical cohort and further supported in the UK Biobank population. Circulating DBH levels were positively associated with blood-pressure traits, consistent with its role as a surrogate marker of sympathetic nervous system activity, and suggesting that reduced DBH levels in MRONJ may reflect altered sympathetic regulation. In a mouse model, pharmacological sympathetic inhibition with propranolol exacerbated jaw osteonecrosis and further suppressed osteoclast activity in the presence of zoledronic acid. Osteoblast–osteoclast co-culture experiments demonstrated additive inhibitory effects on osteoclast differentiation under β-adrenergic blockade. Together, these findings support an association between reduced circulating DBH levels and MRONJ and suggest that sympathetic dysregulation may contribute to disease pathogenesis. Circulating DBH may serve as a candidate biomarker for risk assessment and disease monitoring in patients receiving antiresorptive therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, 03080 Republic of Korea",
    "Department of Dental Sciences, School of Dentistry, Seoul National University, Seoul, 08826 Republic of Korea",
    "Institute for Data Innovation in Science, Seoul National University, Seoul, 08826 Republic of Korea",
    "Graduate School of Medical Sciences, Ewha Womans University, Seoul, 03760 Republic of Korea",
    "Department of Dentistry, Institute of Medical Science, Gyeongsang National University School of Medicine, Jinju, 52727 Republic of Korea",
    "Department of Anatomy, School of Medicine, Pusan National University, Yangsan, 50612 Republic of Korea",
    "Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, 03722 Republic of Korea",
    "Dental Multiomics Center, Dental Research Institute, Seoul National University, Seoul, 08826 Republic of Korea",
    "Department of Oral and Maxillofacial Surgery, College of Medicine, Ewha Womans University, Seoul, 03760 Republic of Korea",
    "Ewha Dental AI & Bio Innovation Global Research Institute, Ewha Womans University, Seoul, Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
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        0
      ],
      "name": "Kyeongho Lee"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Hana Cho",
      "orcid": "0000-0002-3591-2013"
    },
    {
      "affs": [
        0
      ],
      "name": "June Yeon Kim"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyun Hwang"
    },
    {
      "affs": [
        3
      ],
      "name": "Ji-Soo Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Soyoung Yoon"
    },
    {
      "affs": [
        1
      ],
      "name": "Sunbin Jung"
    },
    {
      "affs": [
        4
      ],
      "name": "Young-Hoon Kang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yun Hak Kim",
      "orcid": "0000-0002-9796-8266"
    },
    {
      "affs": [
        6
      ],
      "name": "Jun-Young Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Sung-Jin Kim",
      "orcid": "0000-0003-4115-0403"
    },
    {
      "affs": [
        1,
        2,
        7
      ],
      "name": "Hankum Park",
      "orcid": "0000-0001-5795-3249"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Jin-Woo Kim",
      "orcid": "0000-0002-1672-5730"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3w2sx3c1kwea0.bib",
  "cited_by": 0,
  "doi": "10.1038/s12276-026-01868-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737051/",
  "id": "3w2sx3c1kwea0",
  "issns": [
    "1226-3613",
    "2092-6413"
  ],
  "landing_url": "https://doi.org/10.1038/s12276-026-01868-z",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
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      "openalex",
      "2730|Bone health and treatments"
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  "pdf_url": "https://www.nature.com/articles/s12276-026-01868-z.pdf",
  "pmcid": "PMC13737051",
  "pmid": "42875482",
  "published": "2026-10-14",
  "publisher": "Korean Society for Biochemistry and Molecular Biology",
  "ris": "https://research.draconitic.com/paper/3w2sx3c1kwea0.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:21Z",
      "native_id": "PMC13737051",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s12276-026-01868-z"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Bone health and treatments",
      "subfield": "oncology"
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  ],
  "title": "Decreased circulating dopamine β-hydroxylase is associated with medication-related osteonecrosis of the jaw and implicates sympathetic dysregulation",
  "title_text": "Decreased circulating dopamine β-hydroxylase is associated with medication-related osteonecrosis of the jaw and implicates sympathetic dysregulation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:21Z",
  "url": "https://research.draconitic.com/paper/3w2sx3c1kwea0",
  "venue": "Experimental & Molecular Medicine",
  "versions": []
}