{
  "abstract": "1,2-Biscyclopropanes are privileged structural motifs found in natural products, pharmaceuticals, and functional materials, yet their assembly remains challenging. We report the first radical intermolecular strategy for the synthesis of highly functionalized 1,2-biscyclopropanes. Visiblelight-mediated energy transfer (EnT) provides access to a triplet diradical species that, through an ordered intermolecular radical addition, furnishes a rare bis-homoallylic diradical intermediate. This strategy activates the 3-exo-trig radical cyclization triggered by an irreversible intersystem crossing (ISC) step. The method is compatible with naturally occurring functional groups, providing efficient access to polycyclic architectures bearing otherwise inaccessible protic functionalities. Furthermore, the resulting products serve as versatile intermediates for downstream diversification. This work marks a milestone in the development of new mechanistic approaches for the synthesis of highly challenging molecules, highlighting the potential of EnT-enabled diradical reactivity to overcome longstanding limitations in the construction of small rings.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Andrea Serafino"
    },
    {
      "name": "Davide Ruggeri"
    },
    {
      "name": "Giulia Russo"
    },
    {
      "name": "Marco Tommaso Barreca"
    },
    {
      "name": "Raimondo Maggi"
    },
    {
      "name": "Francesco Di Maiolo"
    },
    {
      "name": "Daniele Merli"
    },
    {
      "name": "Luciano Marchiò"
    },
    {
      "name": "Nicola Della Ca"
    },
    {
      "name": "Stefano Protti"
    },
    {
      "name": "Giovanni Maestri"
    },
    {
      "name": "Matteo Lanzi",
      "orcid": "0000-0003-0254-7977"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3w60ejc60dgdb.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008450/v1",
  "fulltext_url": null,
  "id": "3w60ejc60dgdb",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008450/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7211976114",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008450/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3w60ejc60dgdb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008450",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008450/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Visible Light-Mediated Homoallylic Radical Rearrangement for the Intermolecular Synthesis of 1,2-Biscyclopropanes",
  "title_text": "Visible Light-Mediated Homoallylic Radical Rearrangement for the Intermolecular Synthesis of 1,2-Biscyclopropanes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/3w60ejc60dgdb",
  "venue": "ChemRxiv",
  "versions": []
}