{
  "abstract": "Background: Acute pancreatitis (AP) and Crohn’s disease (CD) exhibit overlapping clinical presentations and an unexpectedly high rate of comorbidity. Whether this reflects shared genetic susceptibilities remains unclear. Methods: We performed a cross-trait genome-wide association analysis leveraging European-ancestry summary statistics for AP (Ncases = 8446; Ncontrols = 437,418) and CD (Ncases = 12,194; Ncontrols = 28,072). Firstly, cross-trait genetic correlation was estimated using linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL). Secondly, to pinpoint specific pleiotropic loci and prioritize candidate genes, we employed PLACO under a rigorous composite null hypothesis, integrated with Bayesian colocalization and SMR/HEIDI analyses. Finally, we dissected the underlying biological context by mapping tissue-specific regulatory enrichment and pathway convergence using FUMA, MAGMA, and Stratified LD Score Regression (S-LDSC). Results: AP and CD showed significant positive genetic correlation (LDSC: rg = 0.178, SE = 0.079, P = 0.025; HDL: rg = 0.294, SE = 0.096, P = 0.0021). Pleiotropy analyses revealed 86 SNPs and 6 independent genome-wide significant pleiotropic loci (lead variants at 5q33.1, 6q22.33, 7q34, 10q24.2, 15q22.33 and 19q13.11, PPLACO < 5 × 10−8). Colocalization showed suggestive evidence of a shared causal signal at 6q22.33 (PP4 = 0.666). Gene-based tests of the AP-CD cross-trait statistics prioritized eight pleiotropic genes—RSPO3, ATG16L1, SMAD3, FADS1, ZPBP2, FADS2, PRKAA1 and IRGM. Gene-set analyses highlighted IL-23/Th17-related and broader inflammatory response pathways. Conclusions: AP and CD share polygenic susceptibility and converge on immune and inflammatory processes, with prioritized genes pointing to autophagy, lipid metabolism and TGF-β/SMAD-related biology.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine (Central Hospital of Nanchang City), Nanchang, Jiangxi, China",
    "Department of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China",
    "Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China",
    "Postdoctoral Innovation Practice Base, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China",
    "Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China",
    "Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada",
    "Department of General Surgery, Central Hospital of Nanchang City, Nanchang, Jiangxi, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
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        0
      ],
      "name": "Wenbin Xu"
    },
    {
      "affs": [
        1
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      "name": "Aocheng Ji"
    },
    {
      "affs": [
        2
      ],
      "name": "Lu Han"
    },
    {
      "affs": [
        3
      ],
      "name": "Hao Xiong"
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    {
      "affs": [
        4
      ],
      "name": "Yiyi Jin"
    },
    {
      "affs": [
        5
      ],
      "name": "Wen Lin"
    },
    {
      "affs": [
        6
      ],
      "name": "Yonghui Wu"
    },
    {
      "name": "Yun Wang"
    },
    {
      "name": "Huan Zhong"
    },
    {
      "name": "Longxin Xiong"
    },
    {
      "name": "Chunyan Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3w9nsy5evj277.bib",
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  "doi": "10.1371/journal.pone.0353031",
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
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  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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      "/Biology and life sciences/Genetics/Genomics/Genome analysis/Genome annotation"
    ],
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      "plos",
      "/Biology and life sciences/Genetics/Genomics/Genome analysis/Genome-wide association studies"
    ],
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      "/Medicine and health sciences/Gastroenterology and hepatology/Pancreatitis"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0353031&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3w9nsy5evj277.ris",
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    {
      "first_seen": "2026-10-30T12:17:56Z",
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  "title": "From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease",
  "title_text": "From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/3w9nsy5evj277",
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