{
  "abstract": "Background: The benefits and safety of exercise-based rehabilitation across the valve intervention pathway remain uncertain. We assessed its effects on exercise capacity, cardiac function, postoperative recovery, and reported adverse events.\n\nMethods: We searched eight English and Chinese databases for randomised controlled trials of rehabilitation initiated before, around, or after surgical or transcatheter valve intervention. Outcomes were 6-min walk distance (6MWD), peak oxygen uptake (peak VO ₂ ), left ventricular ejection fraction (LVEF), postoperative length of stay, reported adverse events, and pulmonary complications. Principal analyses used random-effects models. We assessed outcome-specific risk of bias with RoB 2 and evidence certainty with GRADE, and performed subgroup interaction and sensitivity analyses. PROSPERO registration: CRD420261509016.\n\nResults: Twenty-nine trials were included. Rehabilitation increased 6MWD (19 trials; mean difference [MD] 40.95 m, 95% CI 27.10 to 54.81), peak VO ₂ [eight trials; standardised mean difference (SMD) 0.32, 0.07 to 0.57], and LVEF (14 trials; MD 4.41 percentage points, 2.26 to 6.56), and shortened postoperative hospital stay (16 trials; MD −1.77 days, −2.41 to −1.13). Reported adverse events were less frequent [14 estimable trials; risk ratio (RR) 0.53, 0.33 to 0.85], as were pulmonary complications (seven trials; RR 0.62, 0.50 to 0.77). Heterogeneity was substantial for 6MWD, LVEF, and hospital stay. Prediction intervals crossed the null for all outcomes except pulmonary complications. The peak VO ₂ result was no longer statistically significant after excluding high-risk results. Evidence certainty was low for pulmonary complications and very low for the other outcomes.\n\nConclusion: Exercise-based rehabilitation may improve functional and postoperative outcomes around valve intervention, but the magnitude and applicability of benefits remain uncertain. Diverse event definitions prevent the pooled adverse-event result from establishing exercise-specific safety. Larger trials with standardised interventions, outcome assessment, and longer follow-up are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiac Surgery, Sichuan Provincial People’s Hospital, Affiliated Hospital of University of Electronic Science and Technology",
    "Department of Urology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shanshan Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Haitao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dian Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Keli Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinlei He"
    },
    {
      "affs": [
        0
      ],
      "name": "Qin Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3wc3c0ptfjpmn.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.2004830",
  "fulltext_url": null,
  "id": "3wc3c0ptfjpmn",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.2004830/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3wc3c0ptfjpmn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.2004830",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.2004830/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2297-055X",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Efficacy and safety of exercise rehabilitation across the valve intervention pathway: A systematic review and meta-analysis",
  "title_text": "Efficacy and safety of exercise rehabilitation across the valve intervention pathway: A systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:07Z",
  "url": "https://research.draconitic.com/paper/3wc3c0ptfjpmn",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}