{
  "abstract": "Living clinical guidelines revise recommendations as evidence emerges, so an AI answer can be faithful to a real guideline and still be out of date. Here we examine this failure using ASCOBench, 288 unique questions in 96 three-turn conversations grounded in versioned American Society of Clinical Oncology (ASCO) breast and prostate cancer guidelines, with oncologist-reviewed reference answers. Oncologists corrected one in four version-sensitive answers drafted by a frontier model, against fewer than one in ten factual ones. Across the guideline corpus, 19 recommendations changed between versions, seven of them reversals, yet only 1 of 14 superseded documents states that it has been replaced. With a strong model, retrieval over several guideline versions made stale answers four times more frequent than answering without retrieval. SentryLine, a verification-first system, lowered incorrect answers to 4.2-5.2% from 9.7-22.9% for baselines across three models. Recognizing change before a guideline declares it remains an open problem.",
  "abstract_shown": true,
  "affiliations": [
    "Arizona State University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "T. Ravi Kumar"
    },
    {
      "name": "A. I. Kaniyar Narayana Iyengar"
    },
    {
      "name": "M. A. Khan"
    },
    {
      "name": "K. Z. R. Khakwani"
    },
    {
      "name": "K. Kathuria"
    },
    {
      "name": "M. B. Sonbol"
    },
    {
      "name": "I. Riaz"
    },
    {
      "affs": [
        0
      ],
      "name": "V. Gupta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3whg3shjx3pap.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.04.756483",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.04.756483v1.full",
  "id": "3whg3shjx3pap",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.04.756483v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "2718|Artificial Intelligence in Healthcare and Education"
    ]
  ],
  "openalex": "W7221461212",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.04.756483v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3whg3shjx3pap.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:04Z",
      "native_id": "10.64898/2026.10.04.756483",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.04.756483v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "Version-aware question answering over living oncology guidelines",
  "title_text": "Version-aware question answering over living oncology guidelines",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:04Z",
  "url": "https://research.draconitic.com/paper/3whg3shjx3pap",
  "venue": "bioRxiv",
  "versions": []
}