{
  "abstract": "This study evaluated the protective effects of Plantago asiatica L. (PAL) extract against acute lower limb ischemia-reperfusion injury (LL-IRI). Network pharmacology and molecular docking identified core targets associated with inflammation, oxidative stress, and apoptosis and indicated stable interactions betweenPAL constituents and these targets. In vivo, PAL improved skeletal muscle pathology and ultrastructural injury in LL-IRI rats, reduced interleukin-1β (IL-1β) and malondialdehyde (MDA) levels, restored superoxide dismutase (SOD) and catalase (CAT) activities and Bcl-2 expression, and suppressed Bax and cleaved Caspase-3. In vitro, PAL promoted the proliferation and migration of lipopolysaccharide (LPS)-injured C2C12 cells, stabilized mitochondrial membrane potential, and modulated apoptosis-related proteins. These findings support the view that PAL protects against LL-IRI by attenuating inflammation and oxidative stress and by regulating apoptosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Interventional Radiology and Vascular Surgery, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China",
    "Department of Radiology, Hainan Modern Women and Children’s Hospital, Haikou 570311, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0
      ],
      "name": "Jiangpeng Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shenmei Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengjiao Zhu",
      "orcid": "0009-0006-2103-9344"
    },
    {
      "affs": [
        1
      ],
      "name": "Jin Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Chuanzhu Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Teng Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Guiyun Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Tang Deng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3wrv6ce7g6vks.bib",
  "cited_by": 0,
  "doi": "10.1515/biol-2025-1381",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726666/?tool=EBI",
  "id": "3wrv6ce7g6vks",
  "issns": [
    "2391-5412"
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  "landing_url": "https://europepmc.org/article/PMC/PMC13726666",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "Research Article"
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      "openalex",
      "2734|Cardiac Ischemia and Reperfusion"
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13726666/pdf/?tool=EBI",
  "pmcid": "PMC13726666",
  "pmid": "42974177",
  "published": "2026-11-02",
  "publisher": "De Gruyter",
  "ris": "https://research.draconitic.com/paper/3wrv6ce7g6vks.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13726666",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13726666"
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    {
      "first_seen": "2026-11-05T12:22:57Z",
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      "url": "https://doi.org/10.1515/biol-2025-1381"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Cardiac Ischemia and Reperfusion",
      "subfield": "general"
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  ],
  "title": "Mechanism of the crude extract from the whole herb of Plantago asiatica L. in alleviating lower limb ischemia-reperfusion injury",
  "title_text": "Mechanism of the crude extract from the whole herb of Plantago asiatica L. in alleviating lower limb ischemia-reperfusion injury",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:33Z",
  "url": "https://research.draconitic.com/paper/3wrv6ce7g6vks",
  "venue": "Open life sciences",
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}