{
  "abstract": "Following myocardial infarction, the CXCL12γ-heparan sulfate-ACKR3 axis emerges as a critical, localized signaling mechanism for cardiac repair. Unlike the α isoform, CXCL12γ exhibits superior affinity for ACKR3. Although genetic disruption of CXCL12γ-heparan sulfate binding impairs postischemic angiogenesis and function, its overexpression rescues these deficits. Mechanistically, cardiomyocyte-specific ACKR3 is vital for the regulation of cardiac function, whereas fibroblast-specific ACKR3 orchestrates a proangiogenic paracrine program. This study identifies CXCL12γ as a noncanonical ligand that activates fibroblast-mediated microvascular expansion via ACKR3, offering a novel therapeutic target to enhance myocardial recovery and preserve cardiac performance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Vincent Duval"
    },
    {
      "name": "Morgane Aubert"
    },
    {
      "name": "Alina Ramazanova"
    },
    {
      "name": "Paul Alayrac"
    },
    {
      "name": "Ecem Sakalli"
    },
    {
      "name": "Clément Cochain"
    },
    {
      "name": "Feriel Hamidou"
    },
    {
      "name": "Alexandra Achab Ali"
    },
    {
      "name": "Jose Vilar"
    },
    {
      "name": "Mathilde Lemitre"
    },
    {
      "name": "Stéphane Camus"
    },
    {
      "name": "Bernard Masri"
    },
    {
      "name": "Ralf Jockers"
    },
    {
      "name": "Julie Dam"
    },
    {
      "name": "Thierry Durroux"
    },
    {
      "name": "Jean-Sébastien Silvestre"
    },
    {
      "name": "Angélique Levoye"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3wt0xz8ev57tx.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacbts.2026.101652",
  "fulltext_url": null,
  "id": "3wt0xz8ev57tx",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://hal.science/hal-05775701v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bc"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.csc"
    ],
    [
      "openalex",
      "2705|Cardiac Fibrosis and Remodeling"
    ]
  ],
  "openalex": "W7203837453",
  "pdf_url": "https://hal.science/hal-05775701/document",
  "pmcid": null,
  "pmid": "42804830",
  "published": "2026-08-24",
  "publisher": "Elsevier on behalf of the American College of Cardiology Foundation",
  "ris": "https://research.draconitic.com/paper/3wt0xz8ev57tx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:47Z",
      "native_id": "hal-05775701",
      "source": "hal",
      "url": "https://hal.science/hal-05775701v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.bc",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.csc",
      "subfield": "cardiovascular"
    }
  ],
  "title": "The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction",
  "title_text": "The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:47Z",
  "url": "https://research.draconitic.com/paper/3wt0xz8ev57tx",
  "venue": "JACC : Basic to Translational Science",
  "versions": []
}