{
  "abstract": "Oxazolines are important heterocycles for a range of industrial applications, and yet their synthesis from simple carboxylic acid and amino alcohol substrates requires multiple steps and stoichiometric reagents. Here, we demonstrate the one-pot direct synthesis using a bifunctional boronic acid/phosphorus(V) catalyst that is shown to catalyze both the amidation and cyclodehydration steps. Different classes of carboxylic acid coupling partners are surveyed, the mechanism for cyclodehydration investigated, and a variety of 2-substituted oxazolines prepared without the addition of stoichiometric reagents.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, United States, 78249"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jacob J. Dalton",
      "orcid": "0009-0003-9668-5760"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher Sandford",
      "orcid": "0000-0002-4015-0674"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3wt8n1hpn7z6w.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010757/v1",
  "fulltext_url": null,
  "id": "3wt8n1hpn7z6w",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010757/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Synthesis and Reactions of Organic Compounds"
    ]
  ],
  "openalex": "W7223103659",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010757/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3wt8n1hpn7z6w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010757",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010757/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis and Reactions of Organic Compounds",
      "subfield": "organic"
    }
  ],
  "title": "One-Pot Synthesis of Oxazolines from Carboxylic Acids and Amino Alcohols using Phosphorus(V) Catalysis",
  "title_text": "One-Pot Synthesis of Oxazolines from Carboxylic Acids and Amino Alcohols using Phosphorus(V) Catalysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/3wt8n1hpn7z6w",
  "venue": "ChemRxiv",
  "versions": []
}