{
  "abstract": "Background\n\nDistinguishing early-onset preeclampsia (EO-PE) from gestational hypertension (GHT) at initial presentation remains challenging, particularly when classical diagnostic features are absent or evolving. We evaluated whether combining the albumin-adjusted ischemia-modified albumin ratio (IMAR) with uterine artery pulsatility index expressed as multiples of the median (UtA-PI MoM) provides complementary information in this setting.Methods\n\nIn this prospective single-center exploratory study, 90 singleton pregnancies (30 EO-PE, 30 GHT, 30 controls) were included. IMAR and UtA-PI MoM were assessed individually and in combination using receiver operating characteristic analysis and logistic regression with bootstrap internal validation.Results\n\nIMAR and UtA-PI MoM were higher in EO-PE than in GHT (p = 0.003 and p < 0.001, respectively), whereas raw IMA did not distinguish the groups. IMAR demonstrated moderate discrimination (AUC 0.727, 95% CI 0.600-0.854), and UtA-PI MoM demonstrated higher performance (AUC 0.844, 95% CI 0.743-0.946). The combined model showed the highest apparent discrimination (AUC 0.898, 95% CI 0.818-0.977; optimism-corrected AUC 0.889), with 83.3% sensitivity and 86.7% specificity at the exploratory operating point.Conclusions\n\nCombining IMAR with UtA-PI MoM may provide complementary information for distinguishing EO-PE from GHT at initial presentation. This exploratory model is not intended to replace established angiogenic biomarkers and requires validation in larger, multicenter studies before clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, SBÜ Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey. serkanozbey1129@gmail.com.",
    "Present address: Department of Obstetrics and Gynecology, Esenyurt Necmi Kadıoğlu State Hospital, Esenyurt District, Istanbul, 34517, Turkey. serkanozbey1129@gmail.com.",
    "Department of Obstetrics and Gynecology, SBÜ Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Serkan Özbey",
      "orcid": "0009-0006-1624-3770"
    },
    {
      "affs": [
        2
      ],
      "name": "Handan Turhan Karakuş",
      "orcid": "0009-0004-0652-3993"
    },
    {
      "affs": [
        2
      ],
      "name": "Alper Gümüş",
      "orcid": "0000-0002-4453-6339"
    },
    {
      "affs": [
        2
      ],
      "name": "Pakizer Banu Kılıçoğlu Dane"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3wy4dg4d67qth.bib",
  "cited_by": 0,
  "doi": "10.1186/s12884-026-09700-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13681896",
  "id": "3wy4dg4d67qth",
  "issns": [
    "1471-2393"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897499",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RG1-991"
    ],
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7170483919",
  "pdf_url": "https://europepmc.org/articles/PMC13681896?pdf=render",
  "pmcid": "PMC13681896",
  "pmid": "42897499",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/3wy4dg4d67qth.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897499",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897499"
    },
    {
      "first_seen": "2026-10-30T13:46:36Z",
      "native_id": "c5d2573af6044618b71cb7f1f725db28",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12884-026-09700-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Pregnancy and preeclampsia studies",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Combined albumin-adjusted ischemia-modified albumin ratio and uterine artery Doppler for differentiating early-onset preeclampsia from gestational hypertension: a prospective exploratory pilot study.",
  "title_text": "Combined albumin-adjusted ischemia-modified albumin ratio and uterine artery Doppler for differentiating early-onset preeclampsia from gestational hypertension: a prospective exploratory pilot study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:36Z",
  "url": "https://research.draconitic.com/paper/3wy4dg4d67qth",
  "venue": "BMC pregnancy and childbirth",
  "versions": []
}