{
  "abstract": "BACKGROUND: This meta-analysis aimed to evaluate whether intraoperative hemoadsorption during cardiopulmonary bypass (CPB) improves postoperative outcomes compared with the standard of care. METHODS: We systematically searched EMBASE, PubMed, and the Cochrane Library for randomized controlled trials (RCTs) comparing hemoadsorption versus standard care in patients undergoing cardiac surgery with CPB. Data were analyzed using a frequentist approach and trial sequential analysis (TSA). The primary outcome was the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI) within 7 days after surgery. The protocol was prospectively registered in PROSPERO (CRD42025634991). RESULTS: A total of six RCTs comprising 798 patients were included. Four RCTs (n = 723; 355 hemoadsorption, 368 control) reported CSA-AKI incidence, which did not significantly differ between groups (RR = 0.93 [95% CI: 0.71-1.21], p = 0.57; I² = 42.0%). Hemoadsorption was not associated with significant differences in secondary outcomes: interleukin-6, tumor necrosis factor, 28-day mortality, SOFA score, and ICU length of stay. CONCLUSION: Hemoadsorption during CPB was not associated with a reduction in CSA-AKI or with improvement in secondary clinical outcomes in elective patients undergoing cardiac surgery. However, the accrued sample represented only 48% of the heterogeneity-adjusted required information size (1,491 patients), and the cumulative Z-curve crossed neither the monitoring nor the futility boundary. REGISTRATION: PROSPERO International Register of Systematic Reviews (CRD42025634991; January 31, 2025).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Osama Abou-Arab"
    },
    {
      "name": "Christophe Beyls"
    },
    {
      "name": "Azrat Ibrahima"
    },
    {
      "name": "Arvind Appa"
    },
    {
      "name": "Hamza Yaha Alshatri"
    },
    {
      "name": "Juliette Colombel"
    },
    {
      "name": "Said Kamel"
    },
    {
      "name": "Mouhamed Djahoum Moussa"
    },
    {
      "name": "Emmanuel Besnier"
    },
    {
      "name": "Khaled Saleh"
    },
    {
      "name": "Yazine Mahjoub"
    },
    {
      "name": "Jihad Mallat"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3x03zdw3sses6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.accpm.2026.101931",
  "fulltext_url": null,
  "id": "3x03zdw3sses6",
  "issns": [
    "2352-5568"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05836831v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.chi"
    ],
    [
      "hal",
      "2.sdv.mhep.csc"
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    [
      "hal",
      "2.sdv.mhep.un"
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    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7223123952",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S235255682600189X/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/3x03zdw3sses6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05836831",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05836831v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.csc",
      "subfield": "cardiovascular"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.chi",
      "subfield": "surgery"
    }
  ],
  "title": "Hemoadsorption to prevent acute kidney injury in elective cardiac surgery: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis",
  "title_text": "Hemoadsorption to prevent acute kidney injury in elective cardiac surgery: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/3x03zdw3sses6",
  "venue": "Anaesthesia Critical Care & Pain Medicine",
  "versions": []
}