{
  "abstract": "Hypoxia is a well-recognized risk factor in several pulmonary vascular diseases, including pulmonary hypertension (PH). Furthermore, hypoxia-associated inflammatory changes enhance the structural and functional changes in the pulmonary artery (PA) of PH patients. Understanding the mechanisms that link hypoxia and inflammation, particularly early in disease, is key to the development of novel therapeutic avenues for PH. Thymic stromal lymphopoietin (TSLP) is an \"early\" inflammatory mediator thought to be critical in diseases such as asthma, chronic obstructive pulmonary disease, and atopic dermatitis. TSLP has canonical effects on the immune system, but can also have non-canonical effects on resident lung cells, for example, airway smooth muscle. Currently, the expression and role of TSLP in the PA are unknown. We hypothesized that locally produced TSLP potentiates the effects of hypoxia in PA remodeling and contractility relevant to PH. Experiments in human PA endothelial cells (PAECs) and smooth muscle cells (PASMCs) found PAECs to be a larger source of TSLP, which targets PASMCs to enhance intracellular Ca2+ responses and contractility to vasoconstrictor agonists, as well as cell proliferation and extracellular matrix deposition, acting via a number of signaling cascades including Stat3 and PI3/Akt. Hypoxia, acting via HIF1α, enhanced PAEC production of TSLP and promoted TSLP effects on PASMCs. Interestingly, TSLP per se enhanced HIF1α. Overall, these novel data highlight a role for TSLP in hypoxia effects on the PA, and thus relevance for inflammation in PH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota USA.",
    "Department of Physiology and Biomedical Engineering Mayo Clinic Rochester Minnesota USA.",
    "Department of Anesthesiology and Intensive Care Brno University Brno Czech Republic.",
    "Department of Neurosurgery Brno University Brno Czech Republic.",
    "Intensive Care Research Brno University Brno Czech Republic."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Michael Thompson"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Martin Helan"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Drake"
    },
    {
      "affs": [
        0
      ],
      "name": "Benjamin Roos"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christina M Pabelick",
      "orcid": "0000-0002-4632-2174"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Y S Prakash",
      "orcid": "0000-0002-2968-224X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3xpmjrwtfw3fx.bib",
  "cited_by": 0,
  "doi": "10.1002/pul2.70450",
  "fulltext_url": "https://europepmc.org/articles/PMC13743863",
  "id": "3xpmjrwtfw3fx",
  "issns": [
    "2045-8932",
    "2045-8940"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999736",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W2896021938",
  "pdf_url": "https://europepmc.org/articles/PMC13743863?pdf=render",
  "pmcid": "PMC13743863",
  "pmid": "42999736",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/3xpmjrwtfw3fx.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42999736",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999736"
    },
    {
      "first_seen": "2026-11-11T12:21:29Z",
      "native_id": "PMC13743863",
      "source": "pmc",
      "url": "https://doi.org/10.1002/pul2.70450"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Pulmonary Hypertension Research and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle.",
  "title_text": "Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-11T12:21:29Z",
  "url": "https://research.draconitic.com/paper/3xpmjrwtfw3fx",
  "venue": "Pulmonary circulation",
  "versions": []
}