{
  "abstract": "Background: Mechanical ventilation is a cornerstone therapy for respiratory failure, but heterogeneous regional pressure distribution can lead to localized lung stress and ventilator-induced lung injury. To accurately investigate these dynamics, physiologically realistic experimental platforms are required. However, current experimental models either rely on simplified mechanical lung analogues or lack the capability to measure spatially resolved intrapulmonary pressure dynamics.\n\nMethods: A biomimetic thorax–lung simulator incorporating an ex vivo porcine lung was used to measure regional intrapulmonary pressures during pressure-controlled mechanical ventilation. The lung was positioned within an airtight thoracic chamber operated at a nominal subatmospheric baseline pressure and connected to an anatomically realistic upper airway model. Pressure signals were recorded simultaneously at seven anatomical locations, including the trachea, main bronchi, and upper and lower lung regions. Ventilation was performed across positive end-expiratory pressure (PEEP) levels ranging from 0 to 20 mbar while maintaining a constant driving pressure of 15 mbar. Regional pressure transmission, pressure-trajectory hysteresis, and Poincaré-derived dispersion were analyzed together with tidal volume and dynamic system compliance.\n\nResults: The platform enabled simultaneous acquisition of regional intrapulmonary pressure signals, airway pressure, flow, and chamber pressure across all investigated ventilator settings. Repeated measurements showed high within-specimen technical repeatability, with repeated median regional pressure values differing by approximately 0.02 mbar. Regional pressure attenuation, pressure-flow indices, and trachea-to-region regression parameters were derived as engineering metrics of pressure transmission. Tidal volume and dynamic system compliance were reconstructed from the synchronized flow and tracheal-pressure signals. In the investigated specimen, peripheral regions showed greater pressure-trajectory hysteresis and pressure-state dispersion at low PEEP than under higher PEEP conditions.\n\nConclusion: The developed platform enables synchronized regional intrapulmonary pressure measurements under controlled mechanical ventilation and showed high short-term within-specimen repeatability. In the investigated specimen, static pressure transmission was largely homogeneous, whereas regional pressure-trajectory dynamics differed between central and peripheral measurement sites, particularly at low PEEP. Increasing PEEP was associated with reduced regional pressure-trajectory hysteresis and variability within this specimen. These findings demonstrate the technical feasibility of the platform and provide a basis for subsequent validation in additional specimens and against independent physiological reference data.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Health Sciences, University of Applied Sciences, Giessen, Germany",
    "Medical Faculty, Justus Liebig University, Giessen, Germany",
    "Institute of Medical Informatics (IMI), Justus-Liebig-University, Giessen, Germany",
    "Faculty of Veterinary Medicine, Small Animal Clinic, Justus Liebig University, Giessen, Germany",
    "Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Giessen, Germany",
    "Institute for Lung Health (ILH), Giessen, Germany",
    "Excellence Cluster Cardio-Pulmonary Institute (CPI), Giessen, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Keywan Sohrabi"
    },
    {
      "affs": [
        2
      ],
      "name": "Jasmin Spaar"
    },
    {
      "affs": [
        0
      ],
      "name": "Tibor Jung"
    },
    {
      "affs": [
        0
      ],
      "name": "Niklas Ostwald"
    },
    {
      "affs": [
        0
      ],
      "name": "Patrick Fischer"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Oskar Seifert"
    },
    {
      "affs": [
        2
      ],
      "name": "Dominik Kraft"
    },
    {
      "affs": [
        1,
        4,
        5,
        6
      ],
      "name": "István Vadász"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3xvj3fj3xehb6.bib",
  "cited_by": 0,
  "doi": "10.3389/fbioe.2026.1907500",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736746/",
  "id": "3xvj3fj3xehb6",
  "issns": [
    "2296-4185"
  ],
  "landing_url": "https://doi.org/10.3389/fbioe.2026.1907500",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Respiratory Support and Mechanisms"
    ]
  ],
  "openalex": "W7223179693",
  "pdf_url": "https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1907500/pdf",
  "pmcid": "PMC13736746",
  "pmid": "42991786",
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3xvj3fj3xehb6.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:08Z",
      "native_id": "PMC13736746",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fbioe.2026.1907500"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Respiratory Support and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Development and technical characterization of a biomimetic thorax simulator for regional intrapulmonary pressure measurement",
  "title_text": "Development and technical characterization of a biomimetic thorax simulator for regional intrapulmonary pressure measurement",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:08Z",
  "url": "https://research.draconitic.com/paper/3xvj3fj3xehb6",
  "venue": "Frontiers in Bioengineering and Biotechnology",
  "versions": []
}