{
  "abstract": "Objective: To evaluate the performance of transcranial Doppler (TCD) in pediatric brain death or death by neurologic criteria (BD/DNC) and factors contributing to discordance between TCD and clinical examination.\n\nMethods: We retrospectively analyzed 512 children admitted to the pediatric intensive care unit between 2016 and 2025 who underwent TCD when the Glasgow Coma Scale score was 3 T. Patients were classified as BD/DNC (n = 47), non-BD/DNC (n = 266), or incomplete determination (n = 199) according to the status of BD/DNC determination. TCD findings and cases of TCD-clinical discordance were analyzed.\n\nResults: TCD findings consistent with BD/DNC were observed in 80.9% (38/47) of the BD/DNC group, none of the non-BD/DNC group, and 58.8% (117/199) of the incomplete determination group. Among 9 patients with clinical examination consistent with BD/DNC but TCD findings inconsistent with BD/DNC, intracranial arterial flow remained detectable. Factors potentially contributing to the discordance included disruption of the closed intracranial system (ventricular drainage, patent anterior fontanelle, or multiple skull fractures; n = 4), venoarterial extracorporeal membrane oxygenation support (n = 1), cerebrovascular malformations (n = 1), and delayed TCD examination (n = 1).\n\nConclusions: TCD findings consistent with BD/DNC strongly support the diagnosis of BD/DNC. Given its noninvasive and bedside applicability, TCD has the potential to be a valuable ancillary tool in pediatric BD/DNC evaluation. However, intracranial arterial flow can still be detected in a subset of children with clinically confirmed BD/DNC, underscoring the importance of considering potential interfering factors when TCD is used as a confirmatory test for pediatric BD/DNC.",
  "abstract_shown": true,
  "affiliations": [
    "Pediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health , ,",
    "Department of Emergency Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Na Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Ningning Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Quan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Suyun Qian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3y1ajtcqe63ba.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1931129",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727551/?tool=EBI",
  "id": "3y1ajtcqe63ba",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727551",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2739|Organ Donation and Transplantation"
    ]
  ],
  "openalex": "W7223007866",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727551/pdf/?tool=EBI",
  "pmcid": "PMC13727551",
  "pmid": "42978741",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3y1ajtcqe63ba.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13727551",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727551"
    },
    {
      "first_seen": "2026-11-06T12:23:24Z",
      "native_id": "PMC13727551",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fped.2026.1931129"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Organ Donation and Transplantation",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Clinical utility and limitations of transcranial Doppler in evaluating pediatric brain death or death by neurologic criteria: a 10-year retrospective study",
  "title_text": "Clinical utility and limitations of transcranial Doppler in evaluating pediatric brain death or death by neurologic criteria: a 10-year retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:43Z",
  "url": "https://research.draconitic.com/paper/3y1ajtcqe63ba",
  "venue": "Frontiers in pediatrics",
  "versions": []
}