{
  "abstract": "Objective\n\nLung adenocarcinoma (LUAD) has a poor prognosis. MZF1-AS1 is highly expressed in lung cancer tissues. This study aims to examine the prognostic role of MZF1-AS1 in LUAD and the molecular mechanisms by which it regulates the miR-27b-3p/KRAS axis.Methods\n\nThis study enrolled 136 patients with LUAD and conducted a 5-year follow-up after treatment. The expression levels of MZF1-AS1, miR-27b-3p, and KRAS were measured in tumor and normal tissues from LUAD patients, as well as in various cell lines. The prognostic value of MZF1-AS1 was evaluated using Cox survival analysis and Kaplan-Meier curve. The cell counting kit-8 (CCK-8) assay and Transwell assay were used to assess cell migration, proliferation and invasion capabilities, respectively. Dual-luciferase reporter (DLR) was used to validate the target-binding relationships between MZF1-AS1 and miR-27b-3p, as well as between miR-27b-3p and KRAS.Results\n\nMZF1-AS1 is upregulated in LUAD tissues and serves as an independent risk factor for LUAD prognosis. In cells, knocking down MZF1-AS1 reduces cancer cell migration, proliferation, and invasion. MZF1-AS1 binds to miR-27b-3p via a competing endogenous RNA (ceRNA) network. miR-27b-3p is downregulated in LUAD tissues and cells; inhibition of miR-27b-3p reverses the protective effects of MZF1-AS1 knockdown. KRAS is a direct target of miR-27b-3p and is upregulated in LUAD tissues. MZF1-AS1 binds to miR-27b-3p, thereby lifting its inhibitory effect on KRAS and promoting cell proliferation and invasion.Conclusion\n\nMZF1-AS1 promotes the growth and invasion of LUAD cell lines by regulating the miR-27b-3p/KRAS axis. This suggests that MZF1-AS1 could be a useful prognostic marker and a potential therapeutic target for LUAD.Clinical trial number\n\nNot applicable.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, Longyan First Affiliated Hospital of Fujian Medical University, Fujian, 364000, China.",
    "Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, 110000, China.",
    "Respiratory Department, Rugao People's Hospital, Rugao, 226500, China.",
    "Thoracic Surgery, Sun Yat-sen University Cancer Center Gansu Hospital, No.2, Xiaoxihu East Street, Lanzhou, 730050, China. xuejijun79@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cuiping Lu"
    },
    {
      "affs": [
        1
      ],
      "name": "Qixiang Zhong"
    },
    {
      "affs": [
        2
      ],
      "name": "Haifeng Kan"
    },
    {
      "affs": [
        3
      ],
      "name": "Jijun Xue"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3y3shcvy6snpf.bib",
  "cited_by": 0,
  "doi": "10.1186/s13062-026-00936-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13753279",
  "id": "3y3shcvy6snpf",
  "issns": [
    "1745-6150"
  ],
  "landing_url": "https://europepmc.org/article/MED/43010020",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7203473754",
  "pdf_url": "https://europepmc.org/articles/PMC13753279?pdf=render",
  "pmcid": "PMC13753279",
  "pmid": "43010020",
  "published": "2026-08-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3y3shcvy6snpf.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43010020",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43010020"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "MZF1-AS1 promotes proliferation and invasion of lung adenocarcinoma cells by regulating the miR-27b-3p/KRAS axis.",
  "title_text": "MZF1-AS1 promotes proliferation and invasion of lung adenocarcinoma cells by regulating the miR-27b-3p/KRAS axis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:44Z",
  "url": "https://research.draconitic.com/paper/3y3shcvy6snpf",
  "venue": "Biology direct",
  "versions": []
}