{
  "abstract": "Background\n\nMetabolic dysfunction-associated steatotic liver disease (MASLD) is common in type 2 diabetes. We investigated the association between monocyte mRNA expression of sodium-glucose cotransporter 2 (SGLT2), the molecular target of luseogliflozin, and changes in the fibrosis-4 (FIB-4) index during treatment with this agent.Methods\n\nThis single-center retrospective observational study used prospectively collected peripheral blood monocyte samples from 82 participants with type 2 diabetes and MASLD who had received luseogliflozin for at least 6 months. Baseline monocyte SGLT2 mRNA expression was measured using quantitative real-time polymerase chain reaction. Clinical and laboratory parameters, including FIB-4 index, were evaluated at baseline and 6 months after luseogliflozin initiation. Changes were calculated as the 6-month value minus the baseline value; therefore, negative values indicated reductions.Results\n\nAfter 6 months, waist circumference, hemoglobin A1c, liver enzyme levels, high-sensitivity C-reactive protein, and the FIB-4 index decreased significantly. Baseline monocyte SGLT2 mRNA expression was negatively correlated with the change in the FIB-4 index, indicating that higher baseline expression was associated with a greater reduction. In multiple regression analyses, natural-log-transformed baseline monocyte SGLT2 mRNA expression remained associated with the change in the FIB-4 index after adjustment for baseline clinical variables.Conclusions\n\nHigher baseline monocyte SGLT2 mRNA expression was associated with a greater reduction in the FIB-4 index after luseogliflozin treatment. This finding should be interpreted as an exploratory association between a cell-specific transcriptomic feature and changes in a fibrosis-related index, rather than as evidence of functional SGLT2 signaling in monocytes or histological fibrosis regression.Graphical abstract\n\nSupplementary information\n\nThe online version contains supplementary material available at https://doi.org/10.1007/s13340-026-00941-2.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Diabetes and Endocrinology, Nerima Hikarigaoka Hospital, Nerima-Ku, 179-0072 Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hideyuki Okuma",
      "orcid": "0009-0009-3194-4286"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3y7e6y20adb3s.bib",
  "cited_by": 0,
  "doi": "10.1007/s13340-026-00941-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13723643",
  "id": "3y7e6y20adb3s",
  "issns": [
    "2190-1678",
    "2190-1686"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968831",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7225006166",
  "pdf_url": "https://europepmc.org/articles/PMC13723643?pdf=render",
  "pmcid": "PMC13723643",
  "pmid": "42968831",
  "published": "2026-10-31",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/3y7e6y20adb3s.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42968831",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968831"
    },
    {
      "first_seen": "2026-11-04T12:22:14Z",
      "native_id": "PMC13723643",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s13340-026-00941-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Baseline monocyte SGLT2 mRNA expression and changes in the fibrosis-4 index after luseogliflozin treatment in participants with type 2 diabetes and MASLD.",
  "title_text": "Baseline monocyte SGLT2 mRNA expression and changes in the fibrosis-4 index after luseogliflozin treatment in participants with type 2 diabetes and MASLD.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:25Z",
  "url": "https://research.draconitic.com/paper/3y7e6y20adb3s",
  "venue": "Diabetology international",
  "versions": []
}