{
  "abstract": "Background: Breast cancer is the most prevalent malignancy in women worldwide, including in Vietnam, where 21,238 new cases were diagnosed in 2020. Neoadjuvant chemotherapy (NAC) is commonly used as a preoperative treatment to reduce tumor size, increase breast-conserving surgery rates, and evaluate chemotherapy response.The objectiveof this study was to analyze the outcomes of breast cancer patients treated with NAC at a large tertiary hospital in Vietnam.\n\nMethods: This retrospective real-world study used routine hospital-based clinical records from Cho Ray Hospital. We included 101 breast cancer patients treated with NAC between 2019 and 2021 who underwent surgery and had postoperative follow-up available for survival analysis. Pathological complete response (pCR) rates and survival outcomes were assessed according to breast cancer subtype and other clinicopathologic factors.\n\nResults: A pCR was achieved in 27.7% of patients, with the highest rates observed in triple-negative (53.9%) and human epidermal growth factor receptor 2 (HER2)-enriched (50.0%) subtypes. Hormone receptor-positive patients had lower pCR rates (19.7%). The mean follow-up duration was 30.8 months, with an overall survival rate of 97% and disease-free survival (DFS) rate of 82.2%. In a parsimonious multivariable Cox model for DFS, adjuvant radiotherapy remained independently associated with better DFS, whereas ypN3 status remained independently associated with worse DFS. Non-compliance with adjuvant radiotherapy, particularly during the coronavirus disease 2019 (COVID-19) pandemic, was associated with poorer outcomes.\n\nConclusions: In this real-world cohort, NAC was associated with favorable short-term oncologic outcomes among high-risk breast cancer patients. These outcomes appeared to be influenced by residual pathological burden and adherence to adjuvant radiotherapy. Further research with larger cohorts and extended follow-up is necessary to better characterize long-term outcomes in Vietnamese breast cancer patients.",
  "abstract_shown": true,
  "affiliations": [
    "Breast Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam",
    "Department of Surgery, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam",
    "Cancer Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Khanh Quang Huynh",
      "orcid": "0000-0002-1403-0257"
    },
    {
      "affs": [
        0
      ],
      "name": "Toan Duc Nguyen",
      "orcid": "0009-0002-0229-6477"
    },
    {
      "affs": [
        1
      ],
      "name": "Khiem Tran Dang",
      "orcid": "0000-0001-9354-8267"
    },
    {
      "affs": [
        2
      ],
      "name": "Anh Tuan Le",
      "orcid": "0009-0008-2502-4582"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3ybx8naczj6we.bib",
  "cited_by": 0,
  "doi": "10.21037/tbcr-2026-1-0002",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736016/",
  "id": "3ybx8naczj6we",
  "issns": [
    "2218-6778"
  ],
  "landing_url": "https://doi.org/10.21037/tbcr-2026-1-0002",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ]
  ],
  "openalex": "W7204025594",
  "pdf_url": null,
  "pmcid": "PMC13736016",
  "pmid": "42991463",
  "published": "2026-06-10",
  "publisher": "AME Publications",
  "ris": "https://research.draconitic.com/paper/3ybx8naczj6we.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:34Z",
      "native_id": "PMC13736016",
      "source": "pmc",
      "url": "https://doi.org/10.21037/tbcr-2026-1-0002"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Real-world neoadjuvant chemotherapy outcomes in Vietnamese breast cancer patients: a retrospective analysis",
  "title_text": "Real-world neoadjuvant chemotherapy outcomes in Vietnamese breast cancer patients: a retrospective analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:34Z",
  "url": "https://research.draconitic.com/paper/3ybx8naczj6we",
  "venue": "Translational Breast Cancer Research",
  "versions": []
}