{
  "abstract": "Introduction The indications and modalities of therapeutic strategies for first-onset pure lupus membranous nephropathy (PLMN) remain poorly defined. We aimed to evaluate renal response rates across real-world treatment strategies and identify predictors of treatment response in PLMN. Methods We conducted a multicenter retrospective study in 25 French centers. Patients with biopsy-proven first-onset PLMN treated between 2000 and 2020 were included. Patients were classified according to their initial treatment strategy. Renal response rates were defined based on the 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Factors associated with treatment failure at 12 months were assessed using logistic regression. Results Among 194 patients with PLMN, 53 (27.3%) received supportive care only, and 141 (72.7%) received immunosuppressive therapy (54 [38.3%] received mycophenolate mofetil (MMF)-based regimens, 26 [18.4%] received rituximab [RTX]-based regimens, and 61 [43.3%] received other treatments). At 12 months, rates of complete renal response (CRR) and CRR or partial renal (PRR) were respectively, 36.7% and 55.1% with supportive care, 47.1% and 60.8% with MMF, 64.0% and 72.0% with RTX, and 45.4% and 54.5% with other regimens. In multivariable analysis, the presence of anti–U1-ribonucleoprotein (U1RNP) antibodies was independently associated with treatment failure (adjusted odds ratio [OR]: 2.53; 95% confidence interval [CI]: 1.35–4.70; P = 0.004), whereas extrarenal lupus involvement was protective (adjusted OR=0.39; 95% CI: 0.19–0.73; P = 0.004). RTX-based regimens were significantly associated with shorter treatment duration and corticosteroid sparing. Conclusion In patients with first-onset PLMN, 12-month renal response rates did not differ significantly among immunosuppressive regimens despite variation in treatment duration and steroid exposure. Anti-U1RNP antibodies and absence of extrarenal involvement were associated with a higher risk of treatment failure. Anti-CD20–based strategies may be a promising therapeutic approach.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "name": "Kevin Chevalier"
    },
    {
      "name": "Romain Brousse"
    },
    {
      "name": "Alexandre Karras"
    },
    {
      "name": "Nathalie Costedoat-Chalumeau"
    },
    {
      "name": "Julien Dang"
    },
    {
      "name": "Maxence Tailliar"
    },
    {
      "name": "Noémie Jourde-Chiche"
    },
    {
      "name": "Charles Ronsin"
    },
    {
      "name": "Moglie Le Quintrec-Donnette"
    },
    {
      "name": "Marie Julien"
    },
    {
      "name": "Stanislas Faguer"
    },
    {
      "name": "Aymeric Couturier"
    },
    {
      "name": "Pierre Pommerolle"
    },
    {
      "name": "Céline Lebas"
    },
    {
      "name": "Antoine Coussement"
    },
    {
      "name": "Marion Chapal"
    },
    {
      "name": "Christophe Barba"
    },
    {
      "name": "Alexia Gauffre"
    },
    {
      "name": "Maxime Teisseyre"
    },
    {
      "name": "Johan Noble"
    },
    {
      "name": "Chloé Comarmond"
    },
    {
      "name": "Eve Vilaine"
    },
    {
      "name": "Jean-François Augusto"
    },
    {
      "name": "Aurélie Hummel"
    },
    {
      "name": "Évangéline Pillebout"
    },
    {
      "name": "Jean-Michel Halimi"
    },
    {
      "name": "Olivier Moranne"
    },
    {
      "name": "Eric Daugas"
    },
    {
      "name": "Jean-Jacques Boffa"
    },
    {
      "name": "Emmanuel Esteve"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3yd49ek2y7rds.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ekir.2026.106678",
  "fulltext_url": null,
  "id": "3yd49ek2y7rds",
  "issns": [
    "2468-0249"
  ],
  "landing_url": "https://hal.science/hal-05792957v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2745|Systemic Lupus Erythematosus Research"
    ]
  ],
  "openalex": "W7165530752",
  "pdf_url": "https://www.kireports.org/article/S2468-0249(26)02910-4/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/3yd49ek2y7rds.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "hal-05792957",
      "source": "hal",
      "url": "https://hal.science/hal-05792957v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Outcomes and Predictors of Treatment Response in Patients With Pure Lupus Membranous Nephropathy",
  "title_text": "Outcomes and Predictors of Treatment Response in Patients With Pure Lupus Membranous Nephropathy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:54Z",
  "url": "https://research.draconitic.com/paper/3yd49ek2y7rds",
  "venue": "Kidney International Reports",
  "versions": []
}