{
  "abstract": "Conventional transmission electron microscopy (TEM) records two-dimensional (2D) projections of three-dimensional (3D) objects, complicating the inference of nanoparticle morphology. This limitation is investigated for quasi-spherical iron oxide nanoparticles (IONPs) imaged after deposition on a TEM grid and after cellular internalization and immobilization in resin. A statistical inverse-reconstruction method is developed in which synthetic 3D particle populations are randomly oriented, projected onto a TEM-like plane, and compared with the experimental equivalent-diameter and axial-ratio distributions. Models of increasing geometrical complexity are considered, from monodisperse prolate spheroids to size- and shape-polydisperse prolate populations and triaxial ellipsoids. Size polydispersity is required to reproduce the projected equivalent-diameter distribution, whereas relaxing axial symmetry through a triaxial description enables simultaneous reproduction of the size and axial-ratio distributions. The inferred population represents a statistically compatible 3D morphology rather than a unique particle-by-particle reconstruction. Its physical relevance is assessed through a macrospin model incorporating the corresponding shape-anisotropy contributions. Application to magnetic fluid hyperthermia reveals a pronounced sensitivity of the predicted heating response to particle geometry and polydispersity. The approach provides a general framework for connecting conventional TEM measurements with morphology-dependent properties of nanoparticle ensembles.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.04713",
  "author_total": 9,
  "authors": [
    {
      "name": "Iago López-Vázquez"
    },
    {
      "name": "Amira Páez"
    },
    {
      "name": "Yilian Fernández-Afonso"
    },
    {
      "name": "Roy W. Chantrell"
    },
    {
      "name": "Thomas S. van Zanten"
    },
    {
      "name": "Sergiu Ruta"
    },
    {
      "name": "Lucía Gutiérrez"
    },
    {
      "name": "Òscar Iglesias"
    },
    {
      "name": "David Serantes"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3z68qdk74rzct.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.04713",
  "fulltext_url": null,
  "id": "3z68qdk74rzct",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.04713",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "cond-mat.mtrl-sci"
    ],
    [
      "openalex",
      "2204|Characterization and Applications of Magnetic Nanoparticles"
    ]
  ],
  "openalex": "W7220739225",
  "pdf_url": "https://arxiv.org/pdf/2610.04713",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3z68qdk74rzct.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:01Z",
      "native_id": "2610.04713",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.04713"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:cond-mat.mtrl-sci",
      "subfield": "condensed-matter"
    }
  ],
  "title": "The Hidden Cost of Two-Dimensional TEM Reconstruction of Magnetic Nanoparticle Morphology",
  "title_text": "The Hidden Cost of Two-Dimensional TEM Reconstruction of Magnetic Nanoparticle Morphology",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:01Z",
  "url": "https://research.draconitic.com/paper/3z68qdk74rzct",
  "venue": "arXiv",
  "versions": []
}