{
  "abstract": "Chronic kidney disease (CKD) is a condition that is characterized by persistent tubular injury, inflammation and progressive fibrosis, ultimately leading to an irreversible loss of renal function. Pyroptosis, a notably pro-inflammatory mode of programmed cell death, contributes to tubular epithelial injury and amplifies renal inflammwation. The present study investigated the role of high mobility group nucleosome-binding protein 5 (HMGN5) in CKD and its regulatory relationship with interferon (IFN) receptor 2 (IFNAR2) signaling. The present study found that HMGN5 expression was significantly upregulated in renal tissues obtained from patients with CKD and CKD-model mice; this upregulation was accompanied by enhanced renal injury, fibrosis and inflammatory cytokine production. In vitro, HMGN5 overexpression in HK-2 cells: i) Promoted the expression of IFNAR2, phosphorylated-interferon regulatory factor (IRF)3/IRF7 and absent in melanoma 2; ii) enhanced the cleavage of caspase-1 and gasdermin D; iii) increased IL-1β, IL-8 and IFN-β secretion; and iv) promoted lactate dehydrogenase release. These findings suggested the activation of pyroptosis-associated cellular responses. Conversely, silencing HMGN5 or blocking IFNAR2 signaling markedly attenuated these effects. In vivo, pharmacological blockade of IFNAR2 ameliorated renal tissue damage, reduced fibrosis, restored renal function, decreased systemic cytokine levels and suppressed pyroptosis-associated signaling in CKD-model mice. Collectively, the findings of the present study identified HMGN5 as a novel regulator of IFNAR2-related pyroptosis-associated signaling in renal tubular epithelial cells and suggested that the HMGN5-IFNAR2 axis represents a pathophysiological pathway of interest in CKD that warrants further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Administration Office, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China",
    "Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xue Rong"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jienan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qi Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiangli Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Guoxin Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Limin Nie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3z7dsv82bthyd.bib",
  "cited_by": 0,
  "doi": "10.3892/ijmm.2026.6022",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722481/",
  "id": "3z7dsv82bthyd",
  "issns": [
    "1107-3756",
    "1791-244X"
  ],
  "landing_url": "https://doi.org/10.3892/ijmm.2026.6022",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Articles"
    ],
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7223178971",
  "pdf_url": "http://www.spandidos-publications.com/10.3892/ijmm.2026.6022/download",
  "pmcid": "PMC13722481",
  "pmid": "42924612",
  "published": "2026-10-22",
  "publisher": "Spandidos Publications",
  "ris": "https://research.draconitic.com/paper/3z7dsv82bthyd.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:22:58Z",
      "native_id": "PMC13722481",
      "source": "pmc",
      "url": "https://doi.org/10.3892/ijmm.2026.6022"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "HMGN5 promotes renal tubular inflammation and pyroptosis-associated signaling in chronic kidney disease via the IFNAR2 axis",
  "title_text": "HMGN5 promotes renal tubular inflammation and pyroptosis-associated signaling in chronic kidney disease via the IFNAR2 axis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:58Z",
  "url": "https://research.draconitic.com/paper/3z7dsv82bthyd",
  "venue": "International Journal of Molecular Medicine",
  "versions": []
}