{
  "abstract": "Higher alcohols are major volatile metabolites produced by Saccharomyces cerevisiae. They are traditionally regarded as end products of the Ehrlich pathway. Growing evidence indicates that higher alcohol formation represents a systemic phenotype shaped collectively by nutrient sensing, amino acid uptake, precursor partitioning, carbon source reprogramming, respiratory metabolism, redox homeostasis, and end-product stress. Therefore, higher alcohols serve not only as key aroma compounds, but also as a model system to investigate how yeast integrates environmental cues, metabolism and cellular homeostasis. This review dissects the transcriptional networks regulating higher alcohol biosynthesis. It summarizes nitrogen catabolite repressors Gln3p/Gat1p and Dal80p/Gzf3p; amino acid sensor proteins Stp1p/Stp2p; aromatic branch activator Aro80p; and regulatory proteins involved in precursor supply and metabolic reprogramming, including Leu3p, Gcn4p, Cat8p, Adr1p, Rds2p, Ert1p and the Hap complex. It further discusses the indirect effects of Pdr1p/Pdr3p, Msn2p/Msn4p, Yap1p, Haa1p and War1p via modulation of membrane integrity, redox balance and stress tolerance. Four functional modules are proposed here: substrate input, precursor supply, Ehrlich pathway output, and tolerance maintenance. Three distinct action modes are distinguished: direct pathway activation, precursor remodeling, and high-yield state preservation. This framework explains the condition-dependence and strain specificity of higher alcohol phenotypes. It provides theoretical guidance for subsequent time-resolved omics, chromatin and metabolic flux analyses.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Lu Chen"
    },
    {
      "name": "Yuyang Song"
    },
    {
      "name": "Yanlin Liu"
    },
    {
      "name": "Yi Qin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3z7qwxw6k4s5w.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1980949",
  "fulltext_url": null,
  "id": "3z7qwxw6k4s5w",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1980949",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biology/microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3z7qwxw6k4s5w.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T18:20:51Z",
      "native_id": "10.3389/fmicb.2026.1980949",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1980949"
    },
    {
      "first_seen": "2026-11-03T00:24:27Z",
      "native_id": "10.3389/fmicb.2026.1980949",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1980949/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "feed-journal:biology/microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Transcriptional control of higher alcohol formation in Saccharomyces cerevisiae: a systems framework linking nutrient sensing, precursor allocation, Ehrlich output, and stress adaptation",
  "title_text": "Transcriptional control of higher alcohol formation in Saccharomyces cerevisiae: a systems framework linking nutrient sensing, precursor allocation, Ehrlich output, and stress adaptation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:25:26Z",
  "url": "https://research.draconitic.com/paper/3z7qwxw6k4s5w",
  "venue": "Frontiers in Microbiology",
  "versions": []
}