{
  "abstract": "Background/Objective: Given the high prevalence of vitamin D deficiency, particularly among older women, this post hoc analysis was conducted to evaluate the long-term efficacy and safety of weekly calcifediol 100 µg in women with vitamin D deficiency participating in a randomised, double-blind, phase II/III trial. Methods: A total of 261 women were included (calcifediol, n = 192; placebo, n = 69). The primary objective was to compare the proportions of women achieving serum 25(OH)D concentrations ≥20 ng/mL or ≥30 ng/mL over the 12-month treatment period. Exploratory analyses of body mass index (BMI) and menopausal status were performed. Results: Weekly calcifediol 100 µg demonstrated superior efficacy versus placebo from week 4 in women achieving ≥20 ng/mL (68.2% vs. 5.8%; p < 0.001) or ≥30 ng/mL (21.4% vs. 0%; p < 0.001), and consistently higher proportions were maintained through week 52. Mean 25(OH)D concentrations increased from 12.21 ng/mL at baseline to 39.47 ng/mL at week 16, and remained stable (41–43 ng/mL) thereafter. No significant differences were observed across BMI or menopausal status subgroups. The safety profile of weekly calcifediol 100 µg was similar to placebo, with no evidence of toxicity. Conclusions: Weekly calcifediol 100 µg is a safe and effective option for achieving and maintaining adequate vitamin D levels in vitamin D-deficient women over a period of 12 months, and is associated with consistent effects across BMI and menopausal status.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Río Hortega University Hospital, 47012 Valladolid, Spain",
    "Department of Endocrinology and Nutrition, Quirónsalud Madrid University Hospital, 28223 Madrid, Spain",
    "Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain",
    "Medical Affairs Department, FAES FARMA, 48940 Leioa, Spain",
    "Clinical Development Department, FAES FARMA, 48940 Leioa, Spain"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "José Luis Pérez Castrillón",
      "orcid": "0000-0002-1723-217X"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Esteban Jódar-Gimeno",
      "orcid": "0000-0002-1234-8560"
    },
    {
      "affs": [
        3
      ],
      "name": "Aintzane García-Bea"
    },
    {
      "affs": [
        4
      ],
      "name": "Cristina Martínez Ostalé"
    },
    {
      "affs": [
        4
      ],
      "name": "Inmaculada Gilaberte"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3zbhx5xm7d6wc.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213658",
  "fulltext_url": null,
  "id": "3zbhx5xm7d6wc",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3658",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3zbhx5xm7d6wc.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:38Z",
      "native_id": "10.3390/nu18213658",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3658"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6643",
      "subfield": "nutrition"
    }
  ],
  "title": "Weekly Calcifediol 100 µg in Women with Vitamin D Deficiency: A Post Hoc Analysis of a Randomised Placebo-Controlled Phase II/III Trial",
  "title_text": "Weekly Calcifediol 100 µg in Women with Vitamin D Deficiency: A Post Hoc Analysis of a Randomised Placebo-Controlled Phase II/III Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:24Z",
  "url": "https://research.draconitic.com/paper/3zbhx5xm7d6wc",
  "venue": "Nutrients",
  "versions": []
}