{ "abstract": "Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, revealing that reproductive decline reflects progressive loss of spatiotemporal coordination, linking altered cellular dynamics, tissue remodeling and inflammation across the ovary.", "abstract_shown": true, "affiliations": [ "Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA", "The Broad Institute of MIT and Harvard, Cambridge, MA, USA", "Buck Institute for Research on Aging, Novato, CA, USA", "Department of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA", "Yale College, New Haven, CT, USA", "Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA", "Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA", "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", "Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA", "Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA", "Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA", "Howard Hughes Medical Institute, Chevy Chase, MD, USA", "Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA", "Medical University of Vienna, Comprehensive Center for Artificial Intelligence in Medicine, Vienna, Austria. david.fischer@meduniwien.ac.at", "The Broad Institute of MIT and Harvard, Cambridge, MA, USA. david.fischer@meduniwien.ac.at", "University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria. david.fischer@meduniwien.ac.at", "Buck Institute for Research on Aging, Novato, CA, USA. drjennifergarrison@gmail.com", "Center for Healthy Aging in Women, Novato, CA, USA. drjennifergarrison@gmail.com", "Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. drjennifergarrison@gmail.com", "Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. drjennifergarrison@gmail.com", "Department of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA. hattie.chung@yale.edu", "Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA. hattie.chung@yale.edu", "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA. hattie.chung@yale.edu", "The Broad Institute of MIT and Harvard, Cambridge, MA, USA. hattie.chung@yale.edu", "Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA. hattie.chung@yale.edu" ], "article_type": null, "arxiv": null, "author_total": 19, "authors": [ { "affs": [ 0, 1 ], "name": "Tammy C. T. Lan", "orcid": "0000-0003-0824-6796" }, { "affs": [ 2 ], "name": "Alison Kochersberger", "orcid": "0009-0003-2375-7647" }, { "affs": [ 1 ], "name": "Ruth Raichur", "orcid": "0009-0005-9107-7357" }, { "affs": [ 3 ], "name": "Sophia Szady", "orcid": "0009-0004-5988-1831" }, { "affs": [ 3, 4 ], "name": "Hien Tran" }, { "affs": [ 3, 4 ], "name": "Radiana Simeonova" }, { "affs": [ 3 ], "name": "Ashley Helmuth", "orcid": "0009-0000-6124-666X" }, { "affs": [ 3, 4 ], "name": "Andrew Minagar" }, { "affs": [ 3 ], "name": "Maria José Orozco Fuentes" }, { "affs": [ 1 ], "name": "Vipin Kumar", "orcid": "0000-0003-2533-9089" }, { "affs": [ 1 ], "name": "Giovanni J. Marrero", "orcid": "0000-0003-1587-3624" }, { "affs": [ 1 ], "name": "Irving Barrera" }, { "affs": [ 1 ], "name": "Sarah M. Mangiameli", "orcid": "0000-0002-6799-3436" }, { "affs": [ 5, 6, 7, 8, 1 ], "name": "Alex K. Shalek", "orcid": "0000-0001-5670-8778" }, { "affs": [ 9, 10, 11, 1 ], "name": "Pardis Christine Sabeti", "orcid": "0000-0002-9843-1890" }, { "affs": [ 12, 1 ], "name": "Fei Chen", "orcid": "0000-0003-2308-3649" }, { "affs": [ 13, 14, 15 ], "name": "David S. Fischer", "orcid": "0000-0002-1293-7656" }, { "affs": [ 16, 17, 18, 19 ], "name": "Jennifer L. Garrison", "orcid": "0000-0002-5621-2139" }, { "affs": [ 20, 21, 22, 23, 24 ], "name": "Hattie Chung", "orcid": "0000-0001-8417-5606" } ], "bibtex": "https://research.draconitic.com/paper/3zbvsm3fv1nj1.bib", "cited_by": 14, "doi": "10.1038/s43587-026-01140-z", "fulltext_url": null, "id": "3zbvsm3fv1nj1", "issns": [ "2662-8465" ], "landing_url": "https://doi.org/10.1038/s43587-026-01140-z", "language": "en", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "journal", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2739|Reproductive Biology and Fertility" ], [ "openalex", "2743|Reproductive Biology and Fertility" ] ], "openalex": "W7164999503", "pdf_url": null, "pmcid": "PMC13279277", "pmid": "42310395", "published": "2026-06-17", "publisher": "Nature Portfolio", "ris": "https://research.draconitic.com/paper/3zbvsm3fv1nj1.ris", "sources": [ { "first_seen": "2026-10-30T13:26:54Z", "native_id": "W7164999503", "source": "openalex", "url": "https://doi.org/10.1038/s43587-026-01140-z" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2739|Reproductive Biology and Fertility", "subfield": "epidemiology-public-health" }, { "field": "medicine", "origin": "openalex:2743|Reproductive Biology and Fertility", "subfield": "reproductive-child" } ], "title": "Aging disrupts spatiotemporal coordination in the cycling murine ovary", "title_text": "Aging disrupts spatiotemporal coordination in the cycling murine ovary", "type": "peer-reviewed", "updated_at": "2026-11-09T13:21:16Z", "url": "https://research.draconitic.com/paper/3zbvsm3fv1nj1", "venue": "Nature Aging", "versions": [] }