{
  "abstract": "Tumors persist under sustained redox stress by coupling increased reactive-species production to antioxidant buffering, metabolic plasticity and multicellular support. This creates therapeutic vulnerabilities whose tractability depends on the biological state of the exposed compartment. Here, we frame redox nanomedicine as state-matched manipulation of oxidant flux, antioxidant buffering, oxygen and substrate availability, localization, duration and spatial coverage. We propose that therapeutic outcome emerges from chemistry, exposure and the presence of an executable redox dependency together with the machinery required for adaptation, apoptosis, ferroptosis, pyroptosis or cuproptosis. Redox perturbations also propagate through immune, vascular, stromal and metabolic compartments, generating both therapeutic benefits and liabilities. We therefore integrate redox-state dependence, cell-fate assignment, multicompartment effects and translational target engagement into a unified framework. A state-matched development strategy begins with a defined biological dependency, measures local exposure and target engagement, and uses pharmacokinetic, safety and biomarker data to refine product design and patient selection. This framework positions redox nanomedicine as mechanistically testable control of tumor redox states within a defined therapeutic window.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Nuclear Physics and Medical Research Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan, China.",
    "College of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan Province, China.",
    "Department of Oncology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646099, China.",
    "Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.",
    "Nuclear Power Institute of China, Chengdu, Sichuan, China; Sichuan Haitong Isotope Technology Co., Ltd., Chengdu, Sichuan, China.",
    "Sichuan Haitong Isotope Technology Co., Ltd., Chengdu, Sichuan, China.",
    "Nuclear Power Institute of China, Chengdu, Sichuan, China.",
    "Department of Oncology, West China Fourth Hospital, Sichuan University, Chengdu, China. Electronic address: xie.yuping@163.com.",
    "Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Nuclear Physics and Medical Research Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan, China. Electronic address: pxx2014@163.com."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiacheng Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiazhen Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jia Cai"
    },
    {
      "affs": [
        3
      ],
      "name": "Tu Xu"
    },
    {
      "affs": [
        3
      ],
      "name": "Kun Gao"
    },
    {
      "affs": [
        4
      ],
      "name": "Jinsong Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Ning Luo"
    },
    {
      "affs": [
        6
      ],
      "name": "Yaguang Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Yuping Xie"
    },
    {
      "affs": [
        8
      ],
      "name": "Xingchen Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3zg3cmsk7x9rs.bib",
  "cited_by": 0,
  "doi": "10.1016/j.redox.2026.104426",
  "fulltext_url": "https://europepmc.org/articles/PMC13676015",
  "id": "3zg3cmsk7x9rs",
  "issns": [
    "2213-2317"
  ],
  "landing_url": "https://europepmc.org/article/MED/42837695",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Redox biology and oxidative stress"
    ]
  ],
  "openalex": "W7220382050",
  "pdf_url": "https://europepmc.org/articles/PMC13676015?pdf=render",
  "pmcid": "PMC13676015",
  "pmid": "42837695",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3zg3cmsk7x9rs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42837695",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42837695"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Redox biology and oxidative stress",
      "subfield": "molecular-biology"
    }
  ],
  "title": "State-matched redox nanomedicine for cell fate control and multicompartment therapeutic windows.",
  "title_text": "State-matched redox nanomedicine for cell fate control and multicompartment therapeutic windows.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/3zg3cmsk7x9rs",
  "venue": "Redox biology",
  "versions": []
}