{
  "abstract": "OBJECTIVE: Black women experience poor survival from epithelial ovarian cancer (EOC) for all stages at diagnosis and histotypes. The contribution of an ancestry-related genotype in the Atypical Chemokine Receptor 1 (ACKR1) gene to mortality after an EOC diagnosis in Black women has not been previously reported. METHODS: The relationship between the Duffy-null genotype (CC) in the ACKR1 gene and overall post-enrollment mortality in 408 Black women with EOC, including 275 with high-grade serous ovarian cancer (HGSC) was evaluated using Bayesian modeling approach to estimate hazard ratios (HR) and 95% credible intervals (CI) adjusting for stage, age at diagnosis, socioeconomic factors, and ovarian cancer family history. Tumor immune and genetic features were generated from sequencing assays on subsets of the HGSC cases. RESULTS: The CC genotype was associated with reduced all-cause mortality among EOC cases (adjusted HR = 0.60, 95% CI: 0.36-0.99). Among HGSC, the CC genotype was associated with higher African origin, lower ACKR1 expression (p = 0.049), lower cytotoxic T cell abundance (p = 0.062), and a higher frequency of homologous recombination deficient (HRD) tumors (p = 0.051). CONCLUSIONS: In this study, the Duffy-null CC genotype was associated with 40% lower EOC all-cause mortality in Black women. These are hypothesis-generating findings that require replication and further inquiry into mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA",
    "Department of Surgery, Duke University School of Medicine, Durham, NC, USA",
    "Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA",
    "Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA",
    "Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.",
    "Department of Epidemiology, University of Washington, Seattle, Washington",
    "Department of Population Health Sciences and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah USA",
    "Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute, New Brunswick, NJ, USA",
    "Department of Epidemiology, Stanford University, Palo Alto CA, USA",
    "Wayne State University, School of Medicine, Karmanos Cancer Institute Detroit MI",
    "Department of Epidemiology, Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN USA",
    "University of Nebraska Medical Center, College of Public Health, Department of Epidemiology Omaha Nebraska, USA",
    "Tennessee Medical Center Knoxville, TN USA",
    "Department of Human Genetics, Emory University, Atlanta, GA USA",
    "Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA",
    "Usher Institute, School of Medicine, University of Edinburgh, Edinburgh, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
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        0
      ],
      "name": "Joellen M. Schildkraut",
      "orcid": "0009-0001-6446-7676"
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        1
      ],
      "name": "Jeffrey R. Marks"
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        2
      ],
      "name": "Lauren C. Peres"
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    {
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        0
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      "name": "Xintian Song"
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    {
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        3
      ],
      "name": "Anthony J. Alberg"
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    {
      "affs": [
        4,
        5
      ],
      "name": "Katherine A. Lawson-Michod"
    },
    {
      "affs": [
        0
      ],
      "name": "Courtney E. Johnson"
    },
    {
      "affs": [
        0
      ],
      "name": "Lindsay J. Collin"
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        6
      ],
      "name": "Jennifer A. Doherty"
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    {
      "affs": [
        7
      ],
      "name": "Elisa V. Bandera"
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    {
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        8
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      "name": "Melissa L. Bondy"
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    {
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        9
      ],
      "name": "Theresa A. Hastert"
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    {
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        10
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      "name": "Michele L. Coté"
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    {
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        11
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      "name": "Edward S. Peters"
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    {
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        0
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      "name": "Kristin Haller"
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    {
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        12
      ],
      "name": "Paul D. Terry"
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    {
      "affs": [
        13
      ],
      "name": "Michael P. Epstein"
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    {
      "affs": [
        14
      ],
      "name": "Yao Xin"
    },
    {
      "affs": [
        14,
        15
      ],
      "name": "Andrew B. Lawson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3zp2z11c964wf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ygyno.2026.10.024",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729800/",
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    "1095-6859"
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  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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    [
      "heading",
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      "2730|Ovarian cancer diagnosis and treatment"
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  "pdf_url": "https://www.gynecologiconcology-online.net/article/S0090-8258(26)02178-5/pdf",
  "pmcid": "PMC13729800",
  "pmid": "42950522",
  "published": "2026-10-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3zp2z11c964wf.ris",
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    {
      "first_seen": "2026-11-07T12:22:32Z",
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      "origin": "openalex:2730|Ovarian cancer diagnosis and treatment",
      "subfield": "oncology"
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  "title": "The Duffy-Null genotype and epithelial ovarian cancer survival in a cohort of Black women",
  "title_text": "The Duffy-Null genotype and epithelial ovarian cancer survival in a cohort of Black women",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:32Z",
  "url": "https://research.draconitic.com/paper/3zp2z11c964wf",
  "venue": "Gynecologic oncology",
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}