{
  "abstract": "Objective\n\nTo investigate the effect of Naoxueshu Oral Liquid on rats with radiation-induced brain injury.Methods\n\nA total of 108 male Sprague-Dawley rats were randomly assigned to a control group, an irradiated + normal saline group (RBI+NS), and an irradiated + Naoxueshu Oral Liquid group (RBI+NXS). A radiation-induced brain injury model was established by single-dose whole-brain high-energy X-ray irradiation (30 Gy). After irradiation, rats received Naoxueshu Oral Liquid (0.5 mL/100 g/day, gavage) or normal saline for 14 days. Body weight was monitored, cerebral edema was assessed by brain tissue water content on Days 3, 7, and 14, histopathology was evaluated by hematoxylin-eosin (H&E) staining, and Morris water maze training was conducted from Day 8 to Day 13 post-irradiation, followed by the probe trial on Day 14 post-irradiation.Results\n\nBody weight differed significantly among groups after irradiation (Day 3/6/9/12: all p < 0.01). Specifically, at Day 12, body weight was 328.17±20.10 g (control), 258.50±18.87 g (RBI+NS), and 302.83 ± 10.87 g (RBI+NXS); RBI+NXS was higher than RBI+NS (p < 0.01), while control versus RBI+NS remained different (p < 0.01). H&E staining showed widened perineuronal and perivascular spaces after irradiation, which were attenuated by Naoxueshu. In the Morris water maze, RBI+NS rats exhibited prolonged latency and fewer platform crossings; these impairments were improved after Naoxueshu treatment.Conclusion\n\nNaoxueshu Oral Liquid reduced cerebral edema and improved Morris water maze performance in rats after whole-brain irradiation. Because behavioral outcomes were assessed only using the Morris water maze, the cognitive-related findings should be interpreted cautiously.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Fuguang Li"
    },
    {
      "name": "Xiaolong Qu"
    },
    {
      "name": "Kuiyuan Li"
    },
    {
      "name": "Guosong Li"
    },
    {
      "name": "Shifang Zhou"
    },
    {
      "name": "Min Zhao"
    },
    {
      "name": "Chunyu Zhang"
    },
    {
      "name": "Lei Hui"
    },
    {
      "name": "Wenchao Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/40bm64dhhpntf.bib",
  "cited_by": 0,
  "doi": "10.1002/brb3.71801",
  "fulltext_url": "https://europepmc.org/articles/PMC13669539",
  "id": "40bm64dhhpntf",
  "issns": [
    "2162-3279"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875996",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Effects of Radiation Exposure"
    ]
  ],
  "openalex": "W7221861381",
  "pdf_url": "https://europepmc.org/articles/PMC13669539?pdf=render",
  "pmcid": "PMC13669539",
  "pmid": "42875996",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/40bm64dhhpntf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42875996",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875996"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Effects of Radiation Exposure",
      "subfield": "imaging"
    }
  ],
  "title": "Naoxueshu Oral Liquid Attenuates Early Radiation-Induced Brain Injury in Rats.",
  "title_text": "Naoxueshu Oral Liquid Attenuates Early Radiation-Induced Brain Injury in Rats.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/40bm64dhhpntf",
  "venue": "Brain and behavior",
  "versions": []
}