{
  "abstract": "目的探讨儿童急性阑尾炎（AA）伴穿孔患者血清白介素-17（IL-17）、C-C基序趋化因子配体5（CCL5）水平及其诊断价值。方法收集2022年8月至2023年8月期间在河北省石家庄市妇幼保健院接受治疗的AA患儿120例作为研究组，并根据患儿是否伴发穿孔分为穿孔组（44例）和未穿孔组（76例）。另选取同时期在本院进行体检的95例健康者作为对照组。ELISA法检测血清IL-17、CCL5水平；Pearson法分析患儿血清IL-17与CCL5水平相关性；多因素Logistic回归分析患儿发生穿孔的影响因素；受试者工作特征（ROC）曲线评估血清IL-17、CCL5对AA患儿发生穿孔的诊断价值。结果本研究中，AA患儿血清IL-17、CCL5水平升高，且IL-17水平与CCL5水平呈正相关（r=0.669，P<0.05）。与未穿孔组相比，穿孔组患儿血清IL-17、CCL5水平均显著升高（P<0.05）。结果显示，血清IL-17、CCL5、WBC、CRP、N等水平升高是AA患儿发生穿孔的独立影响因素（P<0.05）。血清IL-17、CCL5水平单独及联合诊断AA患儿发生穿孔的AUC分别为0.869、0.827、0.941，两者联合诊断价值高于单独诊断（Z二者联合-IL-17=2.030，P=0.042；Z二者联合-CCL5=2.535，P=0.011）。结论儿童AA伴穿孔患者血清IL-17、CCL5水平升高，两者对儿童AA穿孔具有一定的诊断价值。",
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  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "王佳欢"
    },
    {
      "name": "蔡晓艳"
    },
    {
      "name": "郭帅"
    },
    {
      "name": "吕佳佳"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/40bvrcet87px9.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.011",
  "id": "40bvrcet87px9",
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  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
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  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/40bvrcet87px9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:48Z",
      "native_id": "f6d20889c59a4b6fbf4de58a9f37b79b",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.011"
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  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "儿童急性阑尾炎伴穿孔患者血清IL-17、CCL5水平及其诊断价值",
  "title_text": "儿童急性阑尾炎伴穿孔患者血清IL-17、CCL5水平及其诊断价值",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:48Z",
  "url": "https://research.draconitic.com/paper/40bvrcet87px9",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}