{
  "abstract": "Positive peritoneal washing cytology is an uncommon but potentially clinically relevant finding in cervical cancer. This retrospective cohort study evaluated its association with recurrence, survival, and metastasis-related biomarkers in patients undergoing open surgery for cervical cancer between 2018 and 2023. A total of 120 patients were classified as peritoneal washing cytology-positive (n = 32) or cytology-negative (n = 88). Baseline clinicopathological characteristics were broadly comparable between groups. Kaplan–Meier analysis demonstrated poorer survival among patients with positive cytology. The estimated 5-year overall survival was 43.7% (95% CI, 26.8–59.4%) in the cytology-positive group and 67.9% (95% CI, 55.2–77.8%) in the cytology-negative group, whereas the corresponding 5-year progression-free survival estimates were 36.5% (95% CI, 20.5–52.6%) and 62.4% (95% CI, 49.8–72.8%), respectively. Recurrence was more frequent among cytology-positive patients, particularly distant-organ recurrence. Serum VEGF and tissue MMP-9 levels were higher in the cytology-positive group. In multivariable analysis, positive peritoneal washing cytology remained associated with poorer overall survival after adjustment for selected clinicopathological variables. A combined VEGF/MMP-9 model showed exploratory discrimination for lymph-node metastasis, although the model requires internal and external validation. These findings suggest that positive peritoneal washing cytology may identify a subgroup with adverse outcomes after surgery, but prospective and externally validated studies are required before clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center Gansu Hospital, Lanzhou, Gansu Province, China",
    "Department of Pathology, Sun Yat-Sen University Cancer Center Gansu Hospital, Lanzhou, Gansu Province, China",
    "Translational Medicine Research Center, Sun Yat-Sen University Cancer Center Gansu Hospital, Lanzhou, Gansu, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qianwen Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoqin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiqian Lin"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tao Wang",
      "orcid": "0009-0006-8216-1415"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/40pjx32v0msaq.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051356",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13747380/",
  "id": "40pjx32v0msaq",
  "issns": [
    "0025-7974",
    "1536-5964"
  ],
  "landing_url": "https://doi.org/10.1097/md.0000000000051356",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "5400"
    ],
    [
      "heading",
      "Observational Study"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7225421949",
  "pdf_url": null,
  "pmcid": "PMC13747380",
  "pmid": "42994870",
  "published": "2026-11-06",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/40pjx32v0msaq.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T12:23:26Z",
      "native_id": "PMC13747380",
      "source": "pmc",
      "url": "https://doi.org/10.1097/md.0000000000051356"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Prognostic impact of positive peritoneal washing cytology in surgically treated cervical cancer",
  "title_text": "Prognostic impact of positive peritoneal washing cytology in surgically treated cervical cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:24:16Z",
  "url": "https://research.draconitic.com/paper/40pjx32v0msaq",
  "venue": "Medicine",
  "versions": []
}