{
  "abstract": "Deep brain stimulation (DBS) is an alternative to ablative functional neurosurgeries. The basolateral amygdala (BLA) is a potential DBS target for treating psychiatric disorders. However, understanding the associated behavioral and cognitive effects is necessary for safety and tolerability concerns. Therefore, we investigated potential acute effects of unilateral BLA DBS. Adult male Wistar rats were implanted with monopolar electrodes in the right BLA. In Experiment 1, different groups of animals were stimulated for 10 min with either high-frequency (HFS, 130 Hz) or low-frequency (LFS, 20 Hz) stimulation using different stimulation intensities (0 [Control], 10, 50, or 100 µA). Immediately after stimulation, animals were tested in the elevated plus-maze (EPM) and subsequently in the open field test (OFT). In Experiment 2, two groups of animals were subjected to a fear-conditioning protocol and stimulated with HFS or LFS (50 µA) immediately after conditioning. Animals were then tested for short- (2 h) and long-term (24 h) fear memory consolidation. BLA DBS showed no significant effects on: (i) anxiety-like behavior expression for HFS (p = 0.46) or LFS (p = 0.37); (ii) locomotor activity (HFS, p = 0.12; LFS, p = 0.60), in terms of distance traveled in the OFT, or (iii) fear memory consolidation (HFS, p = 0.31; LFS, p = 0.68). Under the stimulation parameters and experimental conditions tested, acute unilateral BLA DBS did not significantly affect spontaneous locomotor activity, anxiety-like behavior, or fear memory consolidation in rats. These results provide information relevant to the tolerability and safety of amygdala DBS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Counselling and Psychology, Hong Kong Shue Yan University, Hong Kong, China.",
    "Graduation Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, 88040-970, Brazil.",
    "Center of Applied Neuroscience (CeNAp), University Hospital, UFSC, Florianópolis, Santa Catarina, Brazil.",
    "Graduate Program in Automation and Systems Engineering, Technological Center, UFSC, Florianópolis, Santa Catarina, Brazil.",
    "Graduation Program in Medical Sciences, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.",
    "Department of Pathology, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.",
    "Department of Systems and Automation, Technological Center, UFSC, Florianópolis, Santa Catarina, Brazil.",
    "Graduation Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, 88040-970, Brazil. rogerwalz@hotmail.com.",
    "Center of Applied Neuroscience (CeNAp), University Hospital, UFSC, Florianópolis, Santa Catarina, Brazil. rogerwalz@hotmail.com.",
    "Department of Internal Medicine, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, 3rd floor, Florianópolis, Santa Catarina, 88040-970, Brazil. rogerwalz@hotmail.com.",
    "Graduation Program in Medical Sciences, Center of Health Sciences, University Hospital, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. rogerwalz@hotmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Douglas Affonso Formolo"
    },
    {
      "affs": [
        3
      ],
      "name": "Nicholas Roberto Drabowski"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Hiago Murilo Mello"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Alexandre Ademar Hoeller"
    },
    {
      "affs": [
        1,
        2,
        5
      ],
      "name": "Cristiane Ribeiro de Carvalho"
    },
    {
      "affs": [
        3,
        6
      ],
      "name": "Alexandre Trofino Neto"
    },
    {
      "affs": [
        7,
        8,
        9,
        10
      ],
      "name": "Roger Walz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/40yht2yzdx15k.bib",
  "cited_by": 0,
  "doi": "10.1007/s00221-026-07408-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13658534",
  "id": "40yht2yzdx15k",
  "issns": [
    "0014-4819",
    "1432-1106"
  ],
  "landing_url": "https://europepmc.org/article/MED/42862329",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Neurological disorders and treatments"
    ]
  ],
  "openalex": "W7221554131",
  "pdf_url": "https://europepmc.org/articles/PMC13658534?pdf=render",
  "pmcid": "PMC13658534",
  "pmid": "42862329",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/40yht2yzdx15k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42862329",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42862329"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neurological disorders and treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Acute unilateral DBS of the basolateral amygdala does not affect motricity, anxiety-like behavior, or fear memory consolidation in rats.",
  "title_text": "Acute unilateral DBS of the basolateral amygdala does not affect motricity, anxiety-like behavior, or fear memory consolidation in rats.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/40yht2yzdx15k",
  "venue": "Experimental brain research",
  "versions": []
}