{
  "abstract": "Background/Objectives: Gastric cancer (GC) is associated with depletion of short-chain fatty acid (SCFA)-producing gut commensals, and the same taxa are consistently reduced in type 2 diabetes (T2D). Co-existing metabolic disease might therefore be expected to compound GC-associated dysbiosis, but this has not been examined within a single cohort alongside tumor characteristics. Methods: Fecal microbiota of 97 Korean adults (63 with GC, 34 controls) were profiled by 16S rRNA gene sequencing. Composition, α-diversity, and β-diversity were compared between groups, and within the GC cohort by T2D status, H. pylori status, tumor stage, and lesion location. The summed relative abundance of significantly depleted SCFA-producing genera was analyzed as an aggregate measure of SCFA-producer abundance. Comparisons used Mann–Whitney U tests with Benjamini–Hochberg correction; community-level differences were tested by PERMANOVA. Results: SCFA-producer abundance fell from 26.7 ± 16.9% of the fecal community in controls to 6.6 ± 8.3% in patients with GC (p < 0.001; Cliff’s δ = +0.76, 95% CI +0.61 to +0.89). Enriched genera were predominantly oral and opportunistic, accompanied by expansion of Proteobacteria. Community-level separation was confirmed by PERMANOVA (R2 = 0.088, p = 0.001) with homogeneous dispersions. Within the GC cohort, SCFA-producer abundance did not differ by T2D status, H. pylori status, tumor stage, or lesion location (p = 0.125–0.332), though confidence intervals were wide. Conclusions: Depletion of SCFA-producing commensals in gastric cancer extends across the guild rather than individual genera and was not detectably modified by co-existing T2D or tumor characteristics. Within the limits of this cohort, the signature therefore appears to reflect the presence of disease rather than its clinical or metabolic heterogeneity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Food and Nutrition, Changwon National University, Changwon 51140, Republic of Korea",
    "Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon 51140, Republic of Korea",
    "Department of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea",
    "Department of Nutritional Services, Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Da-Hye Gu"
    },
    {
      "affs": [
        1
      ],
      "name": "Amara Zulfiqar",
      "orcid": "0009-0000-5312-0469"
    },
    {
      "affs": [
        2
      ],
      "name": "Sang-Ho Jeong",
      "orcid": "0000-0001-9061-6236"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyun-Hi Kang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyun-Young Joo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jung-Eun Yim",
      "orcid": "0000-0001-8344-1386"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/40zya5y39jr5e.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16100738",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707191/?tool=EBI",
  "id": "40zya5y39jr5e",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/10/738",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7214945689",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707191/pdf/?tool=EBI",
  "pmcid": "PMC13707191",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/40zya5y39jr5e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16100738",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/10/738"
    },
    {
      "first_seen": "2026-10-30T12:21:49Z",
      "native_id": "PMC:PMC13707191",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707191"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Depletion of Short-Chain Fatty Acid-Producing Commensals in Gastric Cancer Is Not Detectably Modified by Type 2 Diabetes or Tumor Characteristics",
  "title_text": "Depletion of Short-Chain Fatty Acid-Producing Commensals in Gastric Cancer Is Not Detectably Modified by Type 2 Diabetes or Tumor Characteristics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:49Z",
  "url": "https://research.draconitic.com/paper/40zya5y39jr5e",
  "venue": "Metabolites",
  "versions": []
}