{
  "abstract": "Background and purpose\n\nHigh-dose-rate endobronchial brachytherapy (HDR-BTE) is an effective technique for the treatment of malignant tracheobronchial tumors. Although two-dimensional (2D) planning provides limited dosimetric information and does not accurately assess the relationship between the catheter and the tumor or the dose delivered to organs at risk (OARs), it continues to be used because it ensures adequate PTV coverage, is associated with low toxicity, and minimizes the risk of catheter displacement by avoiding patient transfer to the CT simulation room.Patient and methods\n\nAn 83-year-old patient with 2D HDR-BTE for tracheal recurrence of previously resected lung adenocarcinoma was analyzed and compared with four simulated 3D plans based on catheter position relative to the tumor volume, while keeping the active length and prescribed dose constant.Results\n\nThe favorable oblique scenario achieved the best PTV coverage (D90: 9.05 Gy; V100: 100%), although with highest V150 (96.47%) and homogeneity index (IH: 5.14). The unfavorable oblique and posterior positions significantly reduced coverage (V100: 51.4% and 61.29%, respectively). The esophagus was the most sensitive organ, showing the highest doses in the posterior orientation of the catheter. The contralateral lung and heart received low doses; while the aorta showed higher doses in the favorable oblique scenario due to the location of the PTV.Conclusions\n\nCatheter orientation in HDR-BTE has a significant impact on PTV coverage and the dose delivered to critical organs. Despite the trend toward 3D planning, there is no direct clinical evidence comparing the two techniques.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Hospital Central de la Defensa Gómez Ulla, CSVE.",
    "Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.",
    "Department of Radiation Protection and Medical Physics, Hospital Central de la Defensa Gómez Ulla, CSVE.",
    "Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.",
    "Department of Pathology, Hospital Central de la Defensa Gómez Ulla, CSVE."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "J Navarro Castellón"
    },
    {
      "affs": [
        2
      ],
      "name": "I Flores Cacho"
    },
    {
      "affs": [
        0
      ],
      "name": "Mc López Carrizosa"
    },
    {
      "affs": [
        0
      ],
      "name": "C Ibáñez Villoslada"
    },
    {
      "affs": [
        0
      ],
      "name": "M Domínguez Morcillo"
    },
    {
      "affs": [
        0
      ],
      "name": "E Carrasco Esteban"
    },
    {
      "affs": [
        0
      ],
      "name": "P Sáez Bueno"
    },
    {
      "affs": [
        0
      ],
      "name": "Z Zalabarría Zarrabeitia"
    },
    {
      "affs": [
        0
      ],
      "name": "A Pontes Sanz"
    },
    {
      "affs": [
        0
      ],
      "name": "N Curiel Pérez"
    },
    {
      "affs": [
        2
      ],
      "name": "Fj San Miguel Avedillo"
    },
    {
      "affs": [
        2
      ],
      "name": "M Cámara Gallego"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "M A Ortega"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Ma Sáez García"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/410y2wk9z2s34.bib",
  "cited_by": 0,
  "doi": "10.7150/ijms.136860",
  "fulltext_url": "https://europepmc.org/articles/PMC13685031",
  "id": "410y2wk9z2s34",
  "issns": [
    "1449-1907"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909360",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3108|Advanced Radiotherapy Techniques"
    ]
  ],
  "openalex": "W7222885569",
  "pdf_url": "https://europepmc.org/articles/PMC13685031?pdf=render",
  "pmcid": "PMC13685031",
  "pmid": "42909360",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/410y2wk9z2s34.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909360",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909360"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3108|Advanced Radiotherapy Techniques",
      "subfield": "applied-instrumentation"
    }
  ],
  "title": "Impact of catheter positioning on planned target volume (PTV) coverage and organs at risk (OARs) in high-dose-rate (HDR) endotracheal brachytherapy: a comparative 2D vs 3D study.",
  "title_text": "Impact of catheter positioning on planned target volume (PTV) coverage and organs at risk (OARs) in high-dose-rate (HDR) endotracheal brachytherapy: a comparative 2D vs 3D study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/410y2wk9z2s34",
  "venue": "International journal of medical sciences",
  "versions": []
}