{
  "abstract": "Previous studies have reported that truncated p53 exhibits pro-tumorigenic properties; however, whether it contributes to immune evasion by influencing the immune microenvironment remains unclear. Here, we report that exon-6-truncated p53 isoforms (E6-trunc p53) inhibit type I interferon (IFN-I) signaling, thereby supporting tumor cell survival and enabling immune evasion. Ectopic expression of E6-trunc p53 reduces T-cell infiltration into tumors and markedly promotes in vivo tumor growth in an immune-dependent manner. Mechanistically, E6-trunc p53 interacts with TBK1, thereby preventing cell-intrinsic activation of innate immune pathways and suppressing IFN-I-mediated antitumor immunity. Additionally, silencing E6-trunc p53 leads to robust upregulation of IFN-I signaling and induces tumor cell death. Deletion of TBK1 or IFN-β markedly rescues the cell death triggered by knockdown of E6-trunc p53. Notably, TP53 truncating mutations correlate inversely with the extent of T-cell infiltration and predict poor responsiveness to immunotherapy in patients with bladder cancer. Collectively, our findings reveal a novel oncogenic role of E6-trunc p53 in modulating IFN-I signaling and driving tumor malignancy and immune evasion.",
  "abstract_shown": true,
  "affiliations": [
    "Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.",
    "School of medicine, Nankai University, Tianjin, 300071, China.",
    "Department of Urology Laboratory, Chinese PLA General Hospital, Beijing, China.",
    "Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.",
    "Medical School of PLA, Beijing, China."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Chi Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Wenjie Wei"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Senming Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhi Li"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Chuang Wang"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Wen Tao"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Yuhao Dong"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Chunyu Liu"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Shun Wu"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Shuo Tian"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qingbo Huang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Baojun Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hongzhao Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xin Ma"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xu Zhang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yan Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/41f2wkr3btrhj.bib",
  "cited_by": 0,
  "doi": "10.7150/ijbs.131491",
  "fulltext_url": "https://europepmc.org/articles/PMC13685605",
  "id": "41f2wkr3btrhj",
  "issns": [
    "1449-2288"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909883",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer-related Molecular Pathways"
    ]
  ],
  "openalex": "W7214590302",
  "pdf_url": "https://europepmc.org/articles/PMC13685605?pdf=render",
  "pmcid": "PMC13685605",
  "pmid": "42909883",
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/41f2wkr3btrhj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909883",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909883"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer-related Molecular Pathways",
      "subfield": "oncology"
    }
  ],
  "title": "Exon-6 truncated p53 Suppresses Innate Immune Responses to Facilitate Immune Evasion in Bladder Cancer.",
  "title_text": "Exon-6 truncated p53 Suppresses Innate Immune Responses to Facilitate Immune Evasion in Bladder Cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/41f2wkr3btrhj",
  "venue": "International journal of biological sciences",
  "versions": []
}