{
  "abstract": "Achromobacter infections pose significant challenges to people with Cystic Fibrosis (CF). It is a growing problem in people with CF because it is difficult to eliminate with antibiotics, leading to chronic lung infections that increasingly acquire antibiotic resistance. Here we identified a cadre of 26 bacteriophages that target clinical Achromobacter isolates. We tested these phages against a collection of 56 Achromobacter isolates and found that all were susceptible to multiple of these phages. We also evaluated whether we could restore the activity of certain antibiotics by using them as adjunctive therapy to phages in vitro. We found that when meropenem (a beta lactam antibiotic) was added to the phages, improved susceptibility (decreased MICs) was demonstrated in many isolates regardless of whether the Achromobacter was initially susceptible to meropenem. The data presented here suggests that combination therapy using meropenem with an active phage should be considered for treatment of Achromobacter infections regardless of pre-existing antibiotic susceptibility.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "name": "Manola Orlotti"
    },
    {
      "name": "Norhan Turki"
    },
    {
      "name": "Marine Tourneur"
    },
    {
      "name": "Phoolwanti Rani"
    },
    {
      "name": "Jesse Leonard"
    },
    {
      "name": "Natasha Kanhirun"
    },
    {
      "name": "Alisha Blanc"
    },
    {
      "name": "Andrew Su"
    },
    {
      "name": "Yixian Huang"
    },
    {
      "name": "Gabriel Koch"
    },
    {
      "name": "Zachary Pride"
    },
    {
      "name": "Joseph Oh"
    },
    {
      "name": "Monica Bates"
    },
    {
      "name": "Alicia Amamoto"
    },
    {
      "name": "Victoria Carrico"
    },
    {
      "name": "Bethzabe Serrano Buelna"
    },
    {
      "name": "Rob Knight"
    },
    {
      "name": "John Bradley"
    },
    {
      "name": "Douglas Conrad"
    },
    {
      "name": "Joseph Pogliano",
      "orcid": "0000-0001-8989-2655"
    },
    {
      "name": "Ana Georgina Cobián Güemes"
    },
    {
      "name": "David T. Pride"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/427e0201whsfe.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11282-w",
  "fulltext_url": null,
  "id": "427e0201whsfe",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11282-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/427e0201whsfe.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:36Z",
      "native_id": "10.1038/s42003-026-11282-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11282-w"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Susceptibility of Achromobacter spp. to bacteriophages and phage/antibiotic combinations",
  "title_text": "Susceptibility of Achromobacter spp. to bacteriophages and phage/antibiotic combinations",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:20:37Z",
  "url": "https://research.draconitic.com/paper/427e0201whsfe",
  "venue": "Communications Biology",
  "versions": []
}