{
  "abstract": "Adipose-derived stem cells (ADSCs) hold substantial therapeutic potential for diabetic foot ulcers (DFUs). However, their efficacy is often limited by poor survival within the harsh microenvironment of chronic wounds. In this study, we developed a multifunctional bio-derived hydrogel composed of gelatin methacrylate (GelMA), glycyrrhizic acid (GA), and ferrous ions (Fe 2+ ) that integrates ADSCs with local microenvironment modulation. This approach targets key pathological challenges in DFUs treatment, including persistent inflammation, impaired angiogenesis, and oxidative stress. The hydrogel demonstrated potent antibacterial, antioxidant, and pro-angiogenic activities. Moreover, it significantly accelerated diabetic wound healing, enhanced re-epithelialization and collagen deposition, and promoted macrophage polarization toward the reparative M2 phenotype, thereby effectively improving the wound microenvironment. These results indicate that the GelMA/GA/Fe@ADSCs hydrogel is a promising regenerative therapy with strong translational potential for DFUs and other chronic wounds.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, China",
    "Department of Burns and Plastic Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210096, China",
    "Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, China; Corresponding author.",
    "Department of Burns and Plastic Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210096, China; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuemei Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiting Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaye Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingyi Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Fengyuan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jue Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qianting Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ming Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Yue Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Dongfeng Zheng"
    },
    {
      "affs": [
        3
      ],
      "name": "Guopu Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/42kfnjfrrs218.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103803",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2590006426010483",
  "id": "42kfnjfrrs218",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103803",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2746|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7225084767",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/42kfnjfrrs218.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T14:21:32Z",
      "native_id": "0335e51e5e1f48e3b1b55bc69440dcfa",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103803"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Wound Healing and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing",
  "title_text": "Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:32Z",
  "url": "https://research.draconitic.com/paper/42kfnjfrrs218",
  "venue": "Materials Today Bio",
  "versions": []
}