{
  "abstract": "Repeated implantation failure (RIF) remains a significant challenge in assisted reproductive technology, with approximately two-thirds of cases attributed to impaired endometrial receptivity. This review highlights the role of autologous platelet-rich plasma (PRP) as a regenerative adjuvant for rehabilitating the uterine environment. Molecular mechanisms and clinical evidence are presented. It is evident that the concentrated growth factors in PRP-such as VEGF, PDGF, and TGF-beta-promote cell proliferation, angiogenesis, immunomodulation and tissue remodeling. Α consistent statistical trend is recognized toward improved clinical pregnancy and live birth rates across multiple meta-analyses. However, a critical methodological-clinical gap is identified, noting that the current evidence base is compromised by a high risk of bias, non-standardized preparation protocols, and inconsistent diagnostic criteria for RIF. While PRP shows significant biological promise in transforming a hostile uterine environment into a receptive one, its routine clinical application is currently cautioned. Until large-scale, properly blinded randomized controlled trials -utilizing standardized ESHRE definitions- are conducted, PRP should be regarded as an experimental tool rather than a validated standard of care.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Medical School, University of Crete, Herakleion, Crete, Greece.",
    "Department of Histology, Medical School, University of Crete, Herakleion, Crete, Greece."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fanourios Makrygiannakis"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Vrekoussis"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Marmara"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aikaterini Berdiaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonis Makrigiannakis"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/42pxbqnmh6n1n.bib",
  "cited_by": 0,
  "doi": "10.3389/frph.2026.1907558",
  "fulltext_url": "https://europepmc.org/articles/PMC13688098",
  "id": "42pxbqnmh6n1n",
  "issns": [
    "2673-3153"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923818",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Reproductive System and Pregnancy"
    ]
  ],
  "openalex": "W7221036440",
  "pdf_url": "https://europepmc.org/articles/PMC13688098?pdf=render",
  "pmcid": "PMC13688098",
  "pmid": "42923818",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/42pxbqnmh6n1n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923818",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923818"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Reproductive System and Pregnancy",
      "subfield": "immunology"
    }
  ],
  "title": "The role of platelet-rich plasma in repeated implantation failure: a review of biological mechanisms and clinical efficacy.",
  "title_text": "The role of platelet-rich plasma in repeated implantation failure: a review of biological mechanisms and clinical efficacy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/42pxbqnmh6n1n",
  "venue": "Frontiers in reproductive health",
  "versions": []
}