{ "abstract": "Zinc may mitigate platinum-induced toxicity through antioxidant, anti-inflammatory and anti-apoptotic effects. We systematically reviewed preclinical in vivo evidence on zinc-based interventions, focusing on organ protection, mechanisms and antitumour efficacy. PubMed, Scopus, Web of Science and supplementary sources were searched for studies in rats and mice. Risk of bias was assessed using SYRCLE, and the findings were synthesised narratively. Database searches identified 1552 records; 25 studies were included following database and supplementary screening. The risk of bias was frequently unclear for sequence generation, allocation concealment and blinding. Most studies investigated cisplatin; fewer evaluated carboplatin, oxaliplatin or combination chemotherapy. Zinc interventions included salts, dietary supplementation, organic complexes and nanoformulations, predominantly administered before platinum exposure. Protective findings were reported across renal, reproductive, nervous, hepatic, haematopoietic and cardiovascular systems. Proposed mechanisms included metallothionein induction, enhanced antioxidant defences and modulation of inflammation and apoptosis. Heterogeneity precluded conclusions about formulation superiority. Limited tumour-bearing evidence indicated that zinc-induced metallothionein may reduce cisplatin activity, whereas bismuth zinc citrate preserved tumour control within the tested model. Methodological weaknesses, heterogeneity and scarce tumour-bearing evidence limit confidence in efficacy and oncological safety. These findings support further preclinical investigation rather than clinical implementation.", "abstract_shown": true, "affiliations": [ "Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 7HB, UK", "Laboratory of Clinical Pharmacology, Aristotle University Campus, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "Department of Neurology, Agios Pavlos General Hospital of Thessaloniki, Leoforos Ethnikis Antistaseos 161, Kalamaria, 55134 Thessaloniki, Greece", "Department of Respiratory Medicine, Cavan & Monaghan Hospital, H12Y7W1 Lisdarn, Cavan, Ireland", "School of Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen’s Green, D02YN77 Dublin, Ireland", "School of Physics, Clinical and Optometric Sciences, Clinical Measurement Physiology, Technological University Dublin, Park House Grangegorman, 191 North Circular Road, D07EWV4 Dublin, Ireland", "Research Team “Histologistas”, Interinstitutional Postgraduate Program “Health and Environmental Factors”, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "Laboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "ENT-Clinic, “George Papanikolaou” General Hospital of Thessaloniki, Leoforos Papanikolaou, Exochi, 57010 Thessaloniki, Greece", "Private Pathology Laboratory “Microdiagnostics”, Mitropoleos 88, 54621 Thessaloniki, Greece", "Third Department of Neurology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "Department of Medical Oncology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia", "Department of Cardiology, Agios Pavlos General Hospital of Thessaloniki, Leoforos Ethnikis Antistaseos 161, Kalamaria, 55134 Thessaloniki, Greece", "Department of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "1st Neurosurgery Department, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Kiriakidi 1, 54636 Thessaloniki, Greece", "Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece", "Laboratory of Clinical Neurophysiology, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Kiriakidi 1, 54636 Thessaloniki, Greece" ], "article_type": null, "arxiv": null, "author_total": 20, "authors": [ { "affs": [ 0, 1, 2 ], "name": "Vasilis Spyridon Tseriotis", "orcid": "0000-0001-5651-7082" }, { "affs": [ 3, 4, 5 ], "name": "Dimitrios Ampazis", "orcid": "0009-0001-0469-4893" }, { "affs": [ 6, 7 ], "name": "Sofia Karachrysafi", "orcid": "0000-0001-6309-8410" }, { "affs": [ 6, 7 ], "name": "Theodora Papamitsou", "orcid": "0000-0002-0709-5407" }, { "affs": [ 1 ], "name": "Dimitrios Kouvelas", "orcid": "0000-0003-3615-9745" }, { "affs": [ 6, 7 ], "name": "Konstantinos Stergiou", "orcid": "0009-0006-0816-6066" }, { "affs": [ 6, 7 ], "name": "Vasileios Fouskas", "orcid": "0009-0008-8520-2897" }, { "affs": [ 1, 8 ], "name": "Pavlos Pavliis" }, { "affs": [ 9 ], "name": "Dimitris Hatzibougias", "orcid": "0000-0002-1435-2379" }, { "affs": [ 9 ], "name": "Sofia Chatzianagnosti", "orcid": "0009-0004-3794-2621" }, { "affs": [ 9 ], "name": "Evangelia Dimitra Dimaki", "orcid": "0009-0004-1210-3848" }, { "affs": [ 7 ], "name": "Ioannis Konstantinidis", "orcid": "0009-0000-1632-821X" }, { "affs": [ 10 ], "name": "Dimitrios Tsiptsios", "orcid": "0000-0002-1601-8788" }, { "affs": [ 11 ], "name": "Konstantinos Lallas", "orcid": "0000-0001-9306-7295" }, { "affs": [ 12 ], "name": "Aleksandar Sič", "orcid": "0009-0002-9093-6998" }, { "affs": [ 13 ], "name": "Vasileios Keramidas", "orcid": "0009-0007-6803-0256" }, { "affs": [ 14 ], "name": "Charalampos Tastanis", "orcid": "0009-0005-8008-667X" }, { "affs": [ 7, 15 ], "name": "Kyriaki Papadopoulou", "orcid": "0000-0002-6138-0970" }, { "affs": [ 16 ], "name": "Angeliki Cheva", "orcid": "0000-0002-5374-1772" }, { "affs": [ 17 ], "name": "Marianthi Arnaoutoglou" } ], "bibtex": "https://research.draconitic.com/paper/43tsy2cst46jv.bib", "cited_by": 0, "doi": "10.3390/ijms27219438", "fulltext_url": null, "id": "43tsy2cst46jv", "issns": [ "1422-0067" ], "landing_url": "https://www.mdpi.com/1422-0067/27/21/9438", "language": null, "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2734|Chemotherapy-induced organ toxicity mitigation" ] ], "openalex": "W7223299288", "pdf_url": null, "pmcid": null, "pmid": null, "published": "2026-10-23", "publisher": "MDPI AG", "ris": "https://research.draconitic.com/paper/43tsy2cst46jv.ris", "sources": [ { "first_seen": "2026-10-30T12:18:57Z", "native_id": "10.3390/ijms27219438", "source": "crossref", "url": "https://www.mdpi.com/1422-0067/27/21/9438" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2734|Chemotherapy-induced organ toxicity mitigation", "subfield": "general" } ], "title": "Platinum-Induced Toxicity and Zinc-Based Interventions: A Systematic Review of Preclinical Evidence", "title_text": "Platinum-Induced Toxicity and Zinc-Based Interventions: A Systematic Review of Preclinical Evidence", "type": "peer-reviewed", "updated_at": "2026-10-30T12:18:57Z", "url": "https://research.draconitic.com/paper/43tsy2cst46jv", "venue": "International Journal of Molecular Sciences", "versions": [] }