{
  "abstract": "Background\n\nLennox-Gastaut syndrome (LGS) is a genetically heterogeneous developmental and epileptic encephalopathy in which variability in long-term cannabidiol (CBD) response remains incompletely understood. We evaluated whether long-term drop-seizure response trajectories to CBD differ according to genetic status.Methods\n\nThis single-center retrospective longitudinal study analyzed systematically collected clinical follow-up data from 61 patients with LGS treated with pharmaceutical-grade CBD; 46 patients with ≥ 24 months of follow-up were included. Patients were classified as pathogenic/likely pathogenic variant-positive (PV+) or variant-negative (PV-). Drop-seizure reduction trajectories were assessed at 3-month intervals over 24 months.Results\n\nDrop-seizure reduction improved rapidly and was sustained over 24 months in both PV+ and PV- groups, with no significant differences between groups at the prespecified comparison time points. Longitudinal response trajectories showed substantial overlap, and sustained response was observed in 76.1% of patients.Conclusion\n\nLong-term drop-seizure response to CBD in LGS was sustained but not stratified by genetic status, supporting a syndrome-level treatment approach irrespective of genetic findings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Division of Pediatric Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ji-Hoon Na",
      "orcid": "0000-0002-3051-2010"
    },
    {
      "affs": [
        0
      ],
      "name": "Hee Yeon Cho"
    },
    {
      "affs": [
        0
      ],
      "name": "Hayoon Jeon"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyunjoo Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Young-Mock Lee"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/441rfw16kzk83.bib",
  "cited_by": 0,
  "doi": "10.1002/cns.71221",
  "fulltext_url": "https://europepmc.org/articles/PMC13725132",
  "id": "441rfw16kzk83",
  "issns": [
    "1755-5930",
    "1755-5949"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968542",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2738|Epilepsy research and treatment"
    ]
  ],
  "openalex": "W7225111283",
  "pdf_url": "https://europepmc.org/articles/PMC13725132?pdf=render",
  "pmcid": "PMC13725132",
  "pmid": "42968542",
  "published": "2026-11-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/441rfw16kzk83.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42968542",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968542"
    },
    {
      "first_seen": "2026-11-04T12:23:35Z",
      "native_id": "PMC13725132",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cns.71221"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Epilepsy research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Long-Term Drop-Seizure Response Patterns to Cannabidiol According to Genetic Status in Lennox-Gastaut Syndrome.",
  "title_text": "Long-Term Drop-Seizure Response Patterns to Cannabidiol According to Genetic Status in Lennox-Gastaut Syndrome.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:28Z",
  "url": "https://research.draconitic.com/paper/441rfw16kzk83",
  "venue": "CNS neuroscience & therapeutics",
  "versions": []
}