{
  "abstract": "We have previously shown that fresh frozen plasma (FFP) and fibrinogen have protective effects in mice with hemorrhagic shock through restoration of endothelial syndecan-1 and reversal of endothelial injury. In the current study, we tested the hypothesis that a combined model of abdominal sepsis and hemorrhagic shock would induce endothelial syndecan-1 shedding and lung injury which could be attenuated by both FFP and fibrinogen. C57BL/6 mice underwent cecal ligation and puncture (CLP) followed by hemorrhagic shock (HS) and fluid resuscitation with lactated Ringer’s (LR), fibrinogen (5 mg/mouse), and FFP, all at 1X shed blood volume. After 24 h, lung tissues and plasma were harvested for assays. CLP + HS induced an increase in alveolar thickness and decreases in lung syndecan-1 and lung neutrophil granule-enzymes (myeloperoxidase, neutrophil elastase, and MMP9), with reciprocal elevations in plasma syndecan-1 and plasma neutrophil granule-enzymes (myeloperoxidase, neutrophil elastase, and MMP9). All these alterations were significantly attenuated by FFP but not by fibrinogen. Additionally, CLP + HS-induced hypotension at 24 h was partially reversed by FFP but not by fibrinogen. Our results suggest that FFP administration was associated with inhibition of CLP + HS-induced neutrophil degranulation to prevent syndecan-1 shedding and lung injury. The present results provide preclinical evidence supporting further investigation of FFP for therapeutic use in traumatic hemorrhagic shock with sepsis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Feng Wu",
      "orcid": "0000-0003-3113-2332"
    },
    {
      "name": "Jody Cantu"
    },
    {
      "name": "Chavi Rehani"
    },
    {
      "name": "Rosemary A. Kozar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/444cmn3b891am.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-73363-4",
  "fulltext_url": null,
  "id": "444cmn3b891am",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-73363-4",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2706|Trauma, Hemostasis, Coagulopathy, Resuscitation"
    ]
  ],
  "openalex": "W7218788851",
  "pdf_url": "https://www.nature.com/articles/s41598-026-73363-4_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/444cmn3b891am.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-73363-4",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-73363-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Trauma, Hemostasis, Coagulopathy, Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Fresh frozen plasma-based resuscitation lessens lung injury in mice with abdominal sepsis and hemorrhagic shock",
  "title_text": "Fresh frozen plasma-based resuscitation lessens lung injury in mice with abdominal sepsis and hemorrhagic shock",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/444cmn3b891am",
  "venue": "Scientific Reports",
  "versions": []
}