{
  "abstract": "Obesity is linked to limited adipose tissue (AT) remodeling capacity, leading to hypertrophic adipocytes, senescence, and inflammation. We used a mouse model expressing mTert (p21 +/Tert ) from the Cdkn1a locus to investigate the role of mTERT in obesity-induced metabolic disorders. Conditional expression of mTERT reduces metabolic disorders associated with obesity. In AT, this is accompanied by a decrease in the number of senescent p21-positive cells, very short telomeres, and oxidative DNA damage. Single nucleus RNA-seq data reveal TERT expression attenuates senescence induced by HFD in particular in adipose stem and progenitor cells (ASPC). We show that ASPC expansion and differentiation are promoted in p21 +/Tert obese mice, thereby reducing metabolic disorders. We further report that mTERT remodels the landscape of macrophages in AT of obese mice. Strikingly, inactivation of mTERT catalytic activity in p21 +/Tert (p21 +/TertCi ) mice suppresses the promotion of adipocyte formation, but neither affects attenuation of senescence nor macrophage remodeling. These results highlight mTERT’s canonical and non-canonical functions in reducing obesity-associated metabolic disorders. Conditional expression of TERT thus appears as a potential therapeutic option for obesity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Laura Braud"
    },
    {
      "name": "Manuel Bernabe"
    },
    {
      "name": "Julien Vernerey"
    },
    {
      "name": "Antonio M.A. Miranda"
    },
    {
      "name": "Andrea Dominguez"
    },
    {
      "name": "Dmitri Churikov"
    },
    {
      "name": "Manon Richaud"
    },
    {
      "name": "Frédéric Jourquin"
    },
    {
      "name": "Liam Mc Allan"
    },
    {
      "name": "Christophe Lachaud"
    },
    {
      "name": "Jesus Gil"
    },
    {
      "name": "Will Scott"
    },
    {
      "name": "Vincent Géli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/446453gvxrsb9.bib",
  "cited_by": 4,
  "doi": "10.1016/j.molmet.2025.102262",
  "fulltext_url": null,
  "id": "446453gvxrsb9",
  "issns": [
    "2212-8778"
  ],
  "landing_url": "https://hal.science/hal-05855011v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1307|Telomeres, Telomerase, and Senescence"
    ]
  ],
  "openalex": "W4414804886",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/446453gvxrsb9.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:25Z",
      "native_id": "hal-05855011",
      "source": "hal",
      "url": "https://hal.science/hal-05855011v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Telomeres, Telomerase, and Senescence",
      "subfield": "cell-biology"
    }
  ],
  "title": "TERT expression attenuates metabolic disorders in obese mice by promoting adipose stem and progenitor cell expansion and differentiation",
  "title_text": "TERT expression attenuates metabolic disorders in obese mice by promoting adipose stem and progenitor cell expansion and differentiation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:25Z",
  "url": "https://research.draconitic.com/paper/446453gvxrsb9",
  "venue": "Molecular metabolism",
  "versions": []
}