{
  "abstract": "Aims: The impact of genotype on arrhythmic risk in sports-active hypertrophic cardiomyopathy (HCM) patients remains unclear. We compared outcomes between genotype-positive (G+) and genotype-negative (G-) athletes with HCM. Methods and results: In this retrospective study, HCM patients actively engaged in sports underwent standardized baseline evaluation and follow-up. The primary endpoint included sudden cardiac death (SCD)/sudden cardiac arrest, appropriate implantable cardioverter-defibrillator (ICD) therapy, sustained ventricular tachycardia/non-sustained ventricular tachycardia (NSVT). Secondary outcomes included a composite of ventricular arrhythmias, atrial fibrillation, ischaemic stroke, and heart-failure hospitalization. Fifty-nine patients [age 40 years (23.2-50.0)] were followed for 6.3 years (3.0-12.6). Twenty-nine participants (49.2%) carried a likely pathogenic or pathogenic variant, most commonly MYBPC3 (44.8%), MYH7 (24.1%), and TNNT2 (17.2%). At inclusion, median sport practice was 6.0 (3.0-10.0) hours per week, with 67.8% of competitors. At last follow-up, 88.1% remained active in sports. The ESC 5-year SCD risk score was slightly higher in G+ compared with G- patients [1.87% (1.47-3.67) vs. 1.54% (1.24-2.20), P = 0.048], but most of the participants were classified as low risk. Ventricular arrhythmias occurred in 20.7% of G+ and 23.3% of G- patients (P = 0.807), with similar event-free survival (P = 0.685). Most ventricular arrhythmias were isolated NSVT (84.6%). Hard ventricular arrhythmic events were limited to two ICD-terminated ventricular fibrillations in G+ patients, one at rest and one during low-intensity exercise. The incidence of the composite secondary cardiovascular outcome was comparable between groups (31.0% vs. 33.3%, P = 0.850). Conclusion: In this exploratory cohort of sports-active HCM patients, ventricular arrhythmic and cardiovascular event rates were similar between G+ and G- participants during follow-up.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Frederic Myon"
    },
    {
      "name": "Mathilde Delatour"
    },
    {
      "name": "Nathalie Behar"
    },
    {
      "name": "François Carré"
    },
    {
      "name": "Erwan Donal"
    },
    {
      "name": "Frédéric Schnell"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44a2ye9m2h97g.bib",
  "cited_by": 0,
  "doi": "10.1093/ehjopen/oeag127",
  "fulltext_url": null,
  "id": "44a2ye9m2h97g",
  "issns": [
    "2752-4191"
  ],
  "landing_url": "https://hal.science/hal-05743423v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2705|Cardiovascular Effects of Exercise"
    ]
  ],
  "openalex": "W7203683652",
  "pdf_url": "https://hal.science/hal-05743423/document",
  "pmcid": null,
  "pmid": "42662846",
  "published": "2026-08-18",
  "publisher": "Oxford University Press on behalf of the European Society of Cardiology",
  "ris": "https://research.draconitic.com/paper/44a2ye9m2h97g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "hal-05743423",
      "source": "hal",
      "url": "https://hal.science/hal-05743423v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Effects of Exercise",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Genotype status and arrhythmic risk in sport participants with hypertrophic cardiomyopathy",
  "title_text": "Genotype status and arrhythmic risk in sport participants with hypertrophic cardiomyopathy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/44a2ye9m2h97g",
  "venue": "European Heart Journal Open",
  "versions": []
}