{
  "abstract": "Objective: This study aimed to investigate the efficacy of indomethacin and bone wax, individually and in combination, in preventing bony bridge formation following growth plate injury in a rat model.\n\nMethods: Fifteen skeletally immature male Wistar rats were randomly allocated into 5 groups: an uninjured control, an injured control, an isolated bone wax group, an isolated indomethacin group, and a combination group receiving both bone wax and indomethacin. Following standardized growth plate injuries to the proximal tibia, the respective interventions were applied. On day 28, bone volume fraction (BV/TV%) and bone mineral density (BMD) were calculated using micro-computed tomography (micro-CT). Data distribution was assessed with the Shapiro–Wilk test, and the 5 groups were compared using the Kruskal–Wallis test; values are reported as median (interquartile range [IQR]), with statistical significance set at P < .05.\n\nResults: All treatment groups showed lower BV/TV% and BMD than the control groups, with the combined bone wax and indomethacin group showing the lowest values. Median BV/TV% was 52.49% (IQR = 14.92-70.71) in the combined group vs. 75.63% (IQR = 69.64-77.12) in the injured control group, and median BMD was 14.56 mg/cm3 (IQR = 9.73-26.35) vs. 128.03 mg/cm3 (IQR = 11.93-184.02), respectively. On Kruskal–Wallis testing, however, these differences were not statistically significant (BV/TV% = P = .513; BMD: P = .247).\n\nConclusion: The combined application of systemic indomethacin and bone wax interposition showed the lowest values for both bone volume fraction and BMD, which may reflect a potential additive effect of attenuating inflammation-driven osteogenesis and physically blocking bony bridging. However, the absence of significant differences underscores the need for further research and clinical trials before their routine clinical application can be recommended.\n\nCite this article as: Aljasim O, Kayikçi K, Vahabi A, Kaya H, Günay H. The effect of indomethacin and bone wax on preventing bony bridging after growth plate injury. Acta Orthop Traumatol Turc.,2026; 60(5), 0783, doi: 10.5152/j.aott.2026.26783.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic Surgery, Ege University Faculty of Medicine, İzmir, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Omar Aljasim",
      "orcid": "0000-0001-7193-0326"
    },
    {
      "affs": [
        0
      ],
      "name": "Kayahan Kayıkcı",
      "orcid": "0000-0001-7671-7604"
    },
    {
      "affs": [
        0
      ],
      "name": "Arman Vahabi",
      "orcid": "0000-0002-8937-6658"
    },
    {
      "affs": [
        0
      ],
      "name": "Hüseyin Kaya",
      "orcid": "0000-0003-1415-1654"
    },
    {
      "affs": [
        0
      ],
      "name": "Hüseyin Günay",
      "orcid": "0000-0003-1122-4459"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44ddg4b1h3hyz.bib",
  "cited_by": 0,
  "doi": "10.5152/j.aott.2026.26783",
  "fulltext_url": "https://www.aott.org.tr/index.php/pub/article/view/4228",
  "id": "44ddg4b1h3hyz",
  "issns": [
    "1017-995X",
    "2589-1294"
  ],
  "landing_url": "https://doi.org/10.5152/j.aott.2026.26783",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RD701-811"
    ],
    [
      "openalex",
      "2713|Bone fractures and treatments"
    ]
  ],
  "openalex": "W7223565776",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Turkish Association of Orthopaedics and Traumatology",
  "ris": "https://research.draconitic.com/paper/44ddg4b1h3hyz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:24Z",
      "native_id": "92f6390988fb477fb74ff01d3414c480",
      "source": "doaj",
      "url": "https://doi.org/10.5152/j.aott.2026.26783"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Bone fractures and treatments",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The effect of indomethacin and bone wax on preventing bony bridging after growth plate injury",
  "title_text": "The effect of indomethacin and bone wax on preventing bony bridging after growth plate injury",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:24Z",
  "url": "https://research.draconitic.com/paper/44ddg4b1h3hyz",
  "venue": "Acta Orthopaedica et Traumatologica Turcica",
  "versions": []
}